ArticleLeukemia2002
Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics.
Article in Leukemia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 91 citations in OpenAlex.
- Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features.Haematologica · 2013Trial
- The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas.Blood advances · 2023Article
- Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease.Blood advances · 2020Article
- Follicular lymphoma.Nature reviews. Disease primers · 2019Review
- Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines.Oncotarget · 2017Article
- A Novel Non-Immunoglobulin (non-Ig)/BCL6 Translocation in Diffuse Large B-Cell Lymphoma Involving Chromosome 10q11.21 Loci and Review on Clinical Consequences of BCL6 Rearrangements.Pathology oncology research : POR · 2016Review
- Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus.Leukemia · 2016Article
- Follicular lymphoma grade 3B: is it a real disease?Haematologica · 2011Article
- t(14;18)-negative follicular lymphomas are associated with a high frequency of BCL6 rearrangement at the alternative breakpoint region.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP.Translational oncology · 2009Article
- Article
- Follicular lymphoma of the thyroid gland.The American journal of surgical pathology · 2009Article
- Analysis of follicular lymphoma by dual-color fluorescence in situ hybridization.Virchows Archiv : an international journal of pathology · 2008Article
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- Molecular pathways in follicular lymphoma.Leukemia · 2007Review
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- Article
- Article
- Follicular lymphoma subgrouping by fluorescence in situ hybridization analysis.Cancer science · 2005Article
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translocations involving the BCL-6 gene are frequently observed in diffuse large B cell lymphoma, but have rarely been reported in follicular lymphoma (FL). We studied a distinct cohort of FLs with a 3q27/BCL-6 gene rearrangement, but lacking the t(14;18) translocation. In 13/15 cases, translocations involved the 3q27 and the 14q32 regions. All cases displayed a marked follicular growth pattern and, in some instances, a monocytoid component. Tumor cells were CD5(-) CD20(+) CD23(-) CD43(-) BCL-6(+), and in the main CD10 negative (n = 10, 71%) and BCL-2 negative (n = 11, 78%). When compared to 20 typical t(14;18)(+) FLs, the presence of large follicles (P = 0.01) and a CD10(-)/BCL-2(-) phenotype were more frequently observed (P = 0.001) in our cohort. Clonal mutations arising in the BCL-6 first intron were observed in 5/7 cases with evidence of intraclonal heterogeneity, consistent with a germinal center origin. No significant difference was found in comparison to t(14;18)(+) FL regarding age, sex, performance status, bone marrow involvement or overall survival. However, in the 3q27(+) FL group, a stage III/IV disease and a bulky mass were less frequently observed. This study indicates that 3q27(+) FL without t(14;18) translocation have peculiar clinico-pathologic features and may correspond to a rare and distinct subtype of lymphoma originating from the germinal center.
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