ArticleJournal of bacteriology2002
Evolution and virulence of serogroup 6 pneumococci on a global scale.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Evidence of Reduced Virulence and Increased Colonization Among Pneumococcal Isolates of Serotype 3 Clade II Lineage in Mice.The Journal of infectious diseases · 2024Article
- Serotype Distribution, Antimicrobial Susceptibility, Multilocus Sequencing Type and Virulence of InvasiveFrontiers in microbiology · 2021Article
- Synthetic avenues towards a tetrasaccharide related toBeilstein journal of organic chemistry · 2018Article
- Streptococcus pneumoniae serogroup 6 clones over two decades.Epidemiology and infection · 2014Article
- Evolution of the capsular gene locus of Streptococcus pneumoniae serogroup 6.Microbiology (Reading, England) · 2011Article
- Synthesis, conjugation, and immunological evaluation of the serogroup 6 pneumococcal oligosaccharides.Chembiochem : a European journal of chemical biology · 2009Article
- Production of a unique pneumococcal capsule serotype belonging to serogroup 6.Microbiology (Reading, England) · 2009Article
- Genetic basis for the new pneumococcal serotype, 6C.Infection and immunity · 2007Article
- Characterization, distribution, and expression of novel genes among eight clinical isolates of Streptococcus pneumoniae.Infection and immunity · 2006Article
- Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex.Emerging infectious diseases · 2005Article
- Clonal analysis of invasive pneumococcal isolates in Scotland and coverage of serotypes by the licensed conjugate polysaccharide pneumococcal vaccine: possible implications for UK vaccine policy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2005Article
- Clinical and environmental isolates of Legionella pneumophila serogroup 1 cannot be distinguished by sequence analysis of two surface protein genes and three housekeeping genes.Applied and environmental microbiology · 2005Article
- Evolutionary genetics of the capsular locus of serogroup 6 pneumococci.Journal of bacteriology · 2004Article
- Phenotypic and genotypic characterization of two penicillin-susceptible serotype 6B Streptococcus pneumoniae clones circulating in Italy.Journal of clinical microbiology · 2003Article
- Genetics of streptococci, lactococci, and enterococci: review of the sixth international conference.Journal of bacteriology · 2002Article
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4 authors.
Funding
Abstract
To study the evolution and virulence of pneumococcal populations, we used multilocus sequence typing to identify the major clones among 212 carriage and invasive isolates expressing capsular serogroup 6 from 39 countries. The global population consisted of 8 major complexes and 6 minor complexes of related clones and 32 clones of diverse origin. Surprisingly, serotype 6A clones evolved by mutation nearly as often as by recombination, whereas serotype 6B clones evolved almost exclusively by recombination (P = 0.0029). This is the first report of population genetic differences among serotypes of this species. The largest clonal complex was associated with invasive disease (P = 0.019) and included a common ancestor for five previously identified drug-resistant clones. The putative ancestors of the major clonal complexes were represented by a greater proportion of carriage isolates than were their descendents (P = 0.001), and the ancestors tended to be less virulent than their descendents in a mouse model of infection. These data suggested that virulent serogroup 6 clones have evolved multiple times from less-virulent ancestral clones.
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