ArticleJournal of bacteriology2002
Chloride, a new environmental signal molecule involved in gene regulation in a moderately halophilic bacterium, Halobacillus halophilus.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Discriminating two bacteria via laser-induced breakdown spectroscopy and artificial neural network.AMB Express · 2023Article
- Establishment of a salt-induced bioremediation platform from marine Vibrio natriegens.Communications biology · 2022Article
- Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.Frontiers in physiology · 2020Review
- ClAmerican journal of physiology. Cell physiology · 2020Review
- Characterization and Salt Response in Recurrent HalotolerantFrontiers in microbiology · 2018Article
- Characterization of the mechanism of prolonged adaptation to osmotic stress of Jeotgalibacillus malaysiensis via genome and transcriptome sequencing analyses.Scientific reports · 2016Article
- PCBs attenuation and abundance of Dehalococcoides spp., bphC, CheA, and flic genes in typical polychlorinated biphenyl-polluted soil under floody and dry soil conditions.Environmental science and pollution research international · 2016Article
- The Ecological Coherence of Temperature and Salinity Tolerance Interaction and Pigmentation in a Non-marineFrontiers in microbiology · 2016Article
- Salt Stress Induced Changes in the Exoproteome of the Halotolerant Bacterium Tistlia consotensis Deciphered by Proteogenomics.PloS one · 2015Article
- Glutamine synthetase 2 is not essential for biosynthesis of compatible solutes in Halobacillus halophilus.Frontiers in microbiology · 2014Article
- Molecular Mechanisms of Adaptation of the Moderately Halophilic Bacterium Halobacillis halophilus to Its Environment.Life (Basel, Switzerland) · 2013Review
- Life under multiple extreme conditions: diversity and physiology of the halophilic alkalithermophiles.Applied and environmental microbiology · 2012Review
- Extremophiles: from abyssal to terrestrial ecosystems and possibly beyond.Die Naturwissenschaften · 2011Review
- Regulation of osmoadaptation in the moderate halophile Halobacillus halophilus: chloride, glutamate and switching osmolyte strategies.Saline systems · 2008Article
- Salinity-dependent switching of osmolyte strategies in a moderately halophilic bacterium: glutamate induces proline biosynthesis in Halobacillus halophilus.Journal of bacteriology · 2007Article
- Glutamate restores growth but not motility in the absence of chloride in the moderate halophile Halobacillus halophilus.Extremophiles : life under extreme conditions · 2007Article
- Autoinducer-2-producing protein LuxS, a novel salt- and chloride-induced protein in the moderately halophilic bacterium Halobacillus halophilus.Applied and environmental microbiology · 2007Article
- Biochemical and molecular characterization of the biosynthesis of glutamine and glutamate, two major compatible solutes in the moderately halophilic bacterium Halobacillus halophilus.Journal of bacteriology · 2006Article
- Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gram-positive, aerobic, moderately halophilic bacterium Halobacillus halophilus is challenged in its environment by frequently changing salt (NaCl) concentrations. Recently, H. halophilus was shown to be the first prokaryote that is dependent on Cl(-) for growth. In a search for the biological function of Cl(-) in this prokaryote, we identified different Cl(-)-dependent processes, which suggests a more general role for Cl(-) in the metabolism of H. halophilus. To analyze the effect of Cl(-) in more detail, we concentrated on one model system, the Cl(-)-dependent production of flagella, and aimed to identify the molecular basis for the Cl(-) dependence of flagellum production. Here, we report that synthesis of the major subunit of the flagellum, FliC, is dependent on the Cl(-) concentration of the medium, as determined by Western blot analyses. The gene encoding FliC was cloned and sequenced, and Northern blot as well as reverse transcriptase PCR analyses revealed that expression of fliC is Cl(-) dependent. FliC is the first protein of known function demonstrated to be synthesized in a Cl(-)-dependent manner in a prokaryote. Two-dimensional gel electrophoresis of cells grown under different conditions revealed five more Cl(-)-induced proteins; these were identified by N-terminal sequencing and database searches to be orthologs of proteins involved in stress response in Bacillus subtilis. The data indicate that Cl(-) is an important environmental signal in this moderate halophile and regulates protein synthesis and gene expression. Furthermore, the data may suggest that Cl(-) plays a role in the signal transduction involved in salt perception by this bacterium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.