ArticleGenetics2002
Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs.BMC genomics · 2023Article
- Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis.Transgenic research · 2008Article
- Dominant suppression of repeat-induced point mutation in Neurospora crassa by a variant catalytic subunit of DNA polymerase zeta.Genetics · 2008Article
- Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A spontaneous mouse hair mutation was identified in a C3H/HeN colony. The mode of inheritance of the mutation was semidominant, with incomplete penetrance when heterozygous. The trait is controlled by a single locus hague (Hag), which was mapped to the telomeric region of chromosome 15. This mutation was shown to be unstable, since its transmission could be switched from semidominant to recessive. To identify the causative gene and the nature of the mutation, hague was introduced into a high-resolution and high-density molecular genetic map. Over 2000 meioses were analyzed and the mutation was mapped to the keratin 2 complex genes. A YAC and BAC physical map of the critical region was then constructed and the gene involved was located in a 600- to 800-kb-long segment. Fourteen genes were mapped to this region; of these, 11 were expressed in the skin (5 epidermic cytokeratin and 6 hard keratin genes), but none were mutated in hague mice.
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Registered trials
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