ArticleGenetics2002
Exploring the envelope. Systematic alteration in the sex-determination system of the nematode caenorhabditis elegans.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Parallel Evolution of X Chromosome-Specific Structural Maintenance of Chromosomes Complexes in Two Nematode Lineages.Molecular biology and evolution · 2025Article
- The regulatory architecture of gene expression variation in Caenorhabditis elegans revealed by multi-strain allele-specific analysis.Genetics · 2025Article
- Five new Caenorhabditis species from Indonesia provide exceptions to Haldane's rule and partial fertility of interspecific hybrids.G3 (Bethesda, Md.) · 2025Article
- The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025Article
- Five newbioRxiv : the preprint server for biology · 2025Article
- Beyond Haldane's rule: Sex-biased hybrid dysfunction for all modes of sex determination.eLife · 2024Review
- It's a trap?! Escape from an ancient, ancestral sex chromosome system and implication of Foxl2 as the putative primary sex-determining gene in a lizard (Anguimorpha; Shinisauridae).Evolution; international journal of organic evolution · 2024Article
- It's a Trap?! Escape from an ancient, ancestral sex chromosome system and implication ofbioRxiv : the preprint server for biology · 2023Article
- An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease.Journal of developmental biology · 2023Review
- Chromosome-Level Genome Assembly Reveals Dynamic Sex Chromosomes in Neotropical Leaf-Litter Geckos (Sphaerodactylidae: Sphaerodactylus).The Journal of heredity · 2022Article
- A male pheromone that improves the quality of the oogenic germline.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Fisher vs. the Worms: Extraordinary Sex Ratios in Nematodes and the Mechanisms that Produce Them.Cells · 2021Review
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- Chromosome-Wide Evolution and Sex Determination in the Three-Sexed NematodeG3 (Bethesda, Md.) · 2019Article
- Assessment and Maintenance of Unigametic Germline Inheritance for C. elegans.Developmental cell · 2019Article
- Demographic consequences of reproductive interference in multi-species communities.BMC ecology · 2018Article
- WorMachine: machine learning-based phenotypic analysis tool for worms.BMC biology · 2018Article
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Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural sexes of the nematode Caenorhabditis elegans are the self-fertilizing hermaphrodite (XX) and the male (XO). The underlying genetic pathway controlling sexual phenotype has been extensively investigated. Mutations in key regulatory genes have been used to create a series of stable populations in which sex is determined not by X chromosome dosage, but in a variety of other ways, many of which mimic the diverse sex-determination systems found in different animal species. Most of these artificial strains have male and female sexes. Each of seven autosomal genes can be made to adopt a role as the primary determinant of sex, and each of the five autosomes can carry the primary determinant, thereby becoming a sex chromosome. Strains with sex determination by fragment chromosomes, episomes, compound chromosomes, or environmental factors have also been constructed. The creation of these strains demonstrates the ease with which one sex-determination system can be transformed into another.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.