ArticleGenetics2002
Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiae.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics.Trends in genetics : TIG · 2018Review
- Structural and functional mapping of Rtg2p determinants involved in retrograde signaling and aging of Saccharomyces cerevisiae.PloS one · 2017Article
- Characterization of fungal RTG2 genes in retrograde signaling of Saccharomyces cerevisiae.FEMS yeast research · 2013Article
- Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae.Genetics · 2013Article
- The retrograde response: when mitochondrial quality control is not enough.Biochimica et biophysica acta · 2013Review
- The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction.Frontiers in physiology · 2012Article
- Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster.Genetics · 2011Article
- Comparing the yeast retrograde response and NF-κB stress responses: implications for aging.Aging cell · 2010Review
- Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse model.Human mutation · 2010Article
- Article
- ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation mice.Nucleic acids research · 2008Article
- Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Molecular and cellular biology · 2004Article
- Article
- Making yeast tremble: yeast models as tools to study neurodegenerative disorders.Neuromolecular medicine · 2003Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Trinucleotide repeats (TNRs) undergo frequent mutations in families affected by TNR diseases and in model organisms. Much of the instability is conferred in cis by the sequence and length of the triplet tract. Trans-acting factors also modulate TNR instability risk, on the basis of such evidence as parent-of-origin effects. To help identify trans-acting modifiers, a screen was performed to find yeast mutants with altered CTG.CAG repeat mutation frequencies. The RTG2 gene was identified as one such modifier. In rtg2 mutants, expansions of CTG.CAG repeats show a modest increase in rate, depending on the starting tract length. Surprisingly, contractions were suppressed in an rtg2 background. This creates a situation in a model system where expansions outnumber contractions, as in humans. The rtg2 phenotype was apparently specific for CTG.CAG repeat instability, since no changes in mutation rate were observed for dinucleotide repeats or at the CAN1 reporter gene. This feature sets rtg2 mutants apart from most other mutants that affect genetic stability both for TNRs and at other DNA sequences. It was also found that RTG2 acts independently of its normal partners RTG1 and RTG3, suggesting a novel function of RTG2 that helps modify CTG.CAG repeat mutation risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.