ArticleGenetics2002
Molecular basis of adaptive convergence in experimental populations of RNA viruses.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Evolution of virulence of a plant RNA virus in developmental stage-structured host populations.Molecular biology and evolution · 2026Article
- Accurate Detection of Convergent Mutations in Large Protein Alignments With ConDor.Genome biology and evolution · 2024Article
- Evolutionary history of the SARS-CoV-2 Gamma variant of concern (P.1): a perfect storm.Genetics and molecular biology · 2022Article
- Intra-Population Competition during Adaptation to Increased Temperature in an RNA Bacteriophage.International journal of molecular sciences · 2021Article
- Experimental virus evolution in cancer cell monolayers, spheroids, and tissue explants.Virus evolution · 2021Article
- The honeybee (Apis mellifera) developmental state shapes the genetic composition of the deformed wing virus-A quasispecies during serial transmission.Scientific reports · 2020Article
- Social evolution of innate immunity evasion in a virus.Nature microbiology · 2019Article
- Parallel molecular evolution and adaptation in viruses.Current opinion in virology · 2019Review
- Introduction of Viral Hemorrhagic Septicemia Virus into Freshwater Cultured Rainbow Trout Is Followed by Bursts of Adaptive Evolution.Journal of virology · 2018Article
- Article
- An in vivo system for directed experimental evolution of rabbit haemorrhagic disease virus.PloS one · 2017Article
- Constrained evolvability of interferon suppression in an RNA virus.Scientific reports · 2016Article
- Experimental macroevolution.Proceedings. Biological sciences · 2016Review
- Evolution in spatially mixed host environments increases divergence for evolved fitness and intrapopulation genetic diversity in RNA viruses.Virus evolution · 2016Article
- Article
- Evaluating the within-host fitness effects of mutations fixed during virus adaptation to different ecotypes of a new host.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Experimental evolution of an RNA virus in cells with innate immunity defects.Virus evolution · 2015Article
- Contribution of silent mutations to thermal adaptation of RNA bacteriophage Qβ.Journal of virology · 2014Article
- Experimental evolution of an oncolytic vesicular stomatitis virus with increased selectivity for p53-deficient cells.PloS one · 2014Article
- Long-term culture at elevated atmospheric CO2 fails to evoke specific adaptation in seven freshwater phytoplankton species.Proceedings. Biological sciences · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterizing the molecular basis of adaptation is one of the most important goals in modern evolutionary genetics. Here, we report a full-genome sequence analysis of 21 independent populations of vesicular stomatitis ribovirus evolved on the same cell type but under different demographic regimes. Each demographic regime differed in the effective viral population size. Evolutionary convergences are widespread both at synonymous and nonsynonymous replacements as well as in an intergenic region. We also found evidence for epistasis among sites of the same and different loci. We explain convergences as the consequence of four factors: (1) environmental homogeneity that supposes an identical challenge for each population, (2) structural constraints within the genome, (3) epistatic interactions among sites that create the observed pattern of covariation, and (4) the phenomenon of clonal interference among competing genotypes carrying different beneficial mutations. Using these convergences, we have been able to estimate the fitness contribution of the identified mutations and epistatic groups. Keeping in mind statistical uncertainties, these estimates suggest that along with several beneficial mutations of major effect, many other mutations got fixed as part of a group of epistatic mutations.
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