ArticleDigestive diseases and sciences2002
Age- and diet-related increase in transepithelial colon permeability of Fischer 344 rats.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Food-derived molecules as regulators of intestinal tight junctions and barrier function: mechanisms and implications.Frontiers in drug delivery · 2026Review
- The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Review
- Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing.Microbiome · 2021Article
- Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging.Frontiers in nutrition · 2021Article
- Intestinal Health of Pigs Upon Weaning: Challenges and Nutritional Intervention.Frontiers in veterinary science · 2021Review
- The microbiome: an emerging key player in aging and longevity.Translational medicine of aging · 2020Article
- A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function.Scientific reports · 2019Article
- Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity.Scientific reports · 2019Article
- Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.PLoS genetics · 2018Article
- Gut microbiome and aging: Physiological and mechanistic insights.Nutrition and healthy aging · 2018Review
- Glucagon-Like Peptide-2 Improve Intestinal Mucosal Barrier Function in Aged Rats.The journal of nutrition, health & aging · 2018Article
- Regulatory effects of saponins fromJournal of ginseng research · 2018Article
- Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice.Frontiers in immunology · 2017Article
- Methionine restriction fundamentally supports health by tightening epithelial barriers.Annals of the New York Academy of Sciences · 2016Review
- Functional Starters for Functional Yogurt.Foods (Basel, Switzerland) · 2015Article
- Aqueous Extract of Agaricus blazei Murrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Diet and host-microbial crosstalk in postnatal intestinal immune homeostasis.Nature reviews. Gastroenterology & hepatology · 2015Review
- Age-associated remodeling of the intestinal epithelial barrier.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation.BMC microbiology · 2010Article
- Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?Neuroscience · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
When transepithelial permeability of rat distal colon is evaluated on the basis of transepithelial electrical resistance, age does not have an effect. Age likewise did not affect the decrease in resistance brought about by phorbol ester exposure. However, age was shown to correlate with increased transepithelial permeability when diffusion of the nonelectrolyte, D-mannitol, was used as an indicator. A phorbol ester-induced increase in transepithelial permeability to D-mannitol was observed to increase with age. Basal permeability to D-mannitol was significantly higher in older rats when the animals were allowed to age on a high-fat diet. Distance from the rectum was shown to be a potential complicating factor in these studies, since distal colon closer to the rectum was observed to have lower transepithelial permeability. The potential effect of such increased leakiness on the increased frequency of colon cancer in older individuals is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.