ReviewDigestive diseases and sciences2002
Genetic bases of autoimmune hepatitis.
Review in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MMF Is an Effective and Safer Treatment Options for Treatment-Naïve Patients With Autoimmune Hepatitis Compared to Azathioprine: A Systematic Review and Meta-Analysis.Journal of digestive diseasesPooled it
- Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease.Frontiers in immunology · 2022Article
- In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana.Viruses · 2020Article
- Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients.Canadian journal of gastroenterology & hepatology · 2019Article
- Autoimmune hepatitis: Appraisal of current treatment guidelines.World journal of hepatology · 2018Review
- Autoimmune hepatitis in Japan: trends in a nationwide survey.Journal of gastroenterology · 2017Article
- Transitioning from Idiopathic to Explainable Autoimmune Hepatitis.Digestive diseases and sciences · 2015Review
- Liver involvement in pediatric celiac disease.World journal of gastroenterology · 2015Review
- Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics.World journal of gastroenterology · 2015Review
- HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population.Journal of clinical and experimental hepatology · 2014Article
- Celiac disease and autoimmunity: review and controversies.Current allergy and asthma reports · 2013Review
- Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation.Digestive diseases and sciences · 2012Review
- Liver complications in celiac disease.Hepatitis monthly · 2011Article
- Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis.Digestive diseases and sciences · 2010Review
- Association of HLA-DR14 with the treatment response in Japanese patients with autoimmune hepatitis.Digestive diseases and sciences · 2010Article
- Long-term treatment outcomes for autoimmune hepatitis in Korea.Journal of Korean medical science · 2010Article
- Pathogenesis and clinical significance of liver injury in celiac disease.Clinical reviews in allergy & immunology · 2009Review
- HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients.Digestive diseases and sciences · 2008Article
- A comparative review of HLA associations with hepatitis B and C viral infections across global populations.World journal of gastroenterology · 2007Review
- Evidence of a genetic basis for the different geographic occurrences of liver/kidney microsomal antibody type 1 in hepatitis C.Digestive diseases and sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our goal was to review the hypotheses in evolution that promise to elucidate the genetic bases of autoimmune hepatitis. DRB1*0301 and DRB1*0401 are the principal risk factors in Britain and the United States. Other susceptibility alleles in different ethnic groups commonly share the same or a similar motif at the critical DRbeta71 position of the HLA class II molecule. Disease severity may be determined by the number of alleles encoding lysine at the DRbeta1 position, the density of dimers presenting antigen, and the avidity of T-cell receptors for the displayed antigen. Concurrence on the same or different chromosomes of other nonspecific autoimmune promoters may also contribute. A negatively charged residue at the P4 position of antigenic peptides is preferred for binding to the disease-susceptibility alleles, and this complex may be recognized by promiscuous T cells. We conclude that autoimmune hepatitis is a model by which to study the genetic bases of autoimmunity.
Indexed as
Identifiers
12395884What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.