ArticleJournal of epidemiology2002
Association between smoking habits and dopamine receptor D2 taqI A A2 allele in Japanese males: a confirmatory study.
Article in Journal of epidemiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis reveals significant association of 3'-UTR VNTR in SLC6A3 with smoking cessation in Caucasian populations.The pharmacogenomics journal · 2016Pooled it
- The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations.Translational psychiatry · 2015Pooled it
- Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2009Pooled it
- Single Nucleotide Polymorphisms WithinCurrent addiction reports · 2024Article
- Dopamine DRD2 and DRD3 Polymorphisms Involvement in Nicotine Dependence in Patients with Treatment-Resistant Mental Disorders.Journal of personalized medicine · 2022Article
- Smoking Genes: A Case-Control Study of Dopamine Transporter Gene (Biomolecules · 2020Article
- Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Molecular neurobiology · 2015Article
- Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population.BMC genetics · 2014Article
- Article
- Genetic analysis of polymorphisms in dopamine receptor and transporter genes for association with smoking among cancer patients.European addiction research · 2013Article
- Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population.BMC medical genetics · 2009Article
- Dopamine D2 receptor Taq IA polymorphism is associated with postoperative nausea and vomiting.Journal of anesthesia · 2008Article
- Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.Behavioral and brain functions : BBF · 2007Article
- Overview of the pharmacogenomics of cigarette smoking.The pharmacogenomics journal · 2007Review
- Significant association of interleukin 8 -251T/A polymorphism with smoking behavior in a Japanese population.Journal of human genetics · 2005Article
- Association between smoking habits and tryptophan hydroxylase gene C218A polymorphism among the Japanese population.Journal of epidemiology · 2004Article
- Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder.Clinical schizophrenia & related psychosesArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous study showed that A2 allele of dopamine D2 (DRD2) TaqI A polymorphism related to smoking habits, which was opposed to the results of studies for Caucasians. In order to confirm our finding, a similar study was conducted for the first-visit outpatients of Aichi Cancer Center Hospital, who participated in HERPACC-II (Hospital-based Epidemiologic Research Program at Aichi Cancer Center-II). Among consecutive 1,577 first-visit patients between November 2000 and February 2001, 800 patients provided a 7 ml of peripheral blood. Smoking habit data were available for 798 participants. Excluding five participants aged < 20 years or > 80 years, the remaining 793 participants (346 males and 447 females) were analyzed. The DRD2 genotype was determined by a new method, polymerase chain reaction with confronting two-pair primers (PCR-CTPP). In males, current smokers were 35.3% of individuals with A1A1 genotype, 43.1% of individuals with A1A2 genotype, and 57.0% of individuals with A2A2 genotype, while in females, they were 19.6%, 14.6%, and 10.9%, respectively. Age-adjusted odds ratio (OR) of current smoking relative to A1A1 was 1.61 (95% confidence interval, 0.71-3.46) for A1A2 and 2.32 (1.02-5.29) for A2A2 in males, and 0.72 (0.32-1.61) and 0.51 (0.22-1.18) in females, respectively. The present study indicated that Japanese males with A2A2 genotype have a higher risk of being current smokers. No association for Japanese females suggested that female smoking behavior is differently affected in biological and/or psychological manner.
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