ArticleMolecular cancer2002
Mapping common deleted regions on 5p15 in cervical carcinoma and their occurrence in precancerous lesions.
Article in Molecular cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the HPV test positivity rate.Journal of cellular and molecular medicine · 2009Pooled it
- Epigenetic Inactivation of the Tumor SuppressorCancers · 2020Article
- Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo.Scientific reports · 2019Article
- Human papillomavirus and genome instability: from productive infection to cancer.Clinics (Sao Paulo, Brazil) · 2018Review
- Copy number variation in archival melanoma biopsies versus benign melanocytic lesions.Cancer biomarkers : section A of Disease markers · 2016Article
- Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha.Molecular cancer · 2008Article
- The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.The Journal of clinical investigation · 2008Article
- Gene discovery in cervical cancer : towards diagnostic and therapeutic biomarkers.Molecular diagnosis & therapy · 2007Review
- Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma.BMC cancer · 2004Article
- Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome.Molecular cancer · 2003Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have shown that the short arm of chromosome 5 (5p) exhibit frequent genetic changes in invasive cervical carcinoma (CC), and that these changes arise early during the carcinogenesis, in precancerous lesions. These data therefore suggest that loss of candidate tumor suppressor genes located on 5p is associated with the development of CC. However, the precise location of 5p deletions is not known.
resultsWe performed a detailed deletion mapping of 5p in 60 cases of invasive CC. We found that 60% of the tumors exhibit a 5p loss of heterozygosity (LOH). The patterns of LOH allowed us to identify two minimal regions of deletions, one at 5p15.3 spanning a 5.5 cM genetic distance and a second site of 7 cM at 5p15.2-15.3. In addition, we also identified 5p deletions in 16% lesions of high-grade cervical intraepithelial neoplasia (CIN). 5p LOH was found in 63% of HPV 16 positive tumors, while only 33% tumors with other HPV-types had 5p LOH. The differences in frequency of 5p LOH between tumors harboring HPV16 in combination with other HPV types and tumors harboring HPV16 DNA alone were significantly higher, suggesting a synergistic effect of high-risk types in causing genomic instability.
conclusionThese findings implicate the presence of tumor suppressor gene(s) on 5p relevant to CC tumorigenesis.
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