Trial reportBritish journal of clinical pharmacology2002
Direct in vivo evidence of a vascular statin: a single dose of cerivastatin rapidly increases vascular endothelial responsiveness in healthy normocholesterolaemic subjects.
Trial report in British journal of clinical pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 95 citations in OpenAlex.
- Effects of atorvastatin on systemic and renal NO dependency in patients with non-diabetic stage II-III chronic kidney disease.British journal of clinical pharmacology · 2014Trial
- Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemia.European journal of clinical pharmacology · 2013Trial
- Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia.Vascular health and risk management · 2008Trial
- Simvastatin improves endothelial function in patents with subclinical hypothyroidism.Heart and vessels · 2007Trial
- Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein.Circulation research · 2004Trial
- Preeclampsia: Insights into pathophysiological mechanisms and preventive strategies.American journal of preventive cardiology · 2025Review
- New Ideas for the Prevention and Treatment of Preeclampsia and Their Molecular Inspirations.International journal of molecular sciences · 2023Review
- Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress.Nutrients · 2022Article
- The role of statins in the prevention of preeclampsia.American journal of obstetrics and gynecology · 2022Review
- The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations.European cardiology · 2019Review
- Article
- Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris.Heart and vessels · 2017Article
- Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease.Clinical cardiology · 2016Article
- Statins as first-line therapy for acute coronary syndrome?Experimental and clinical cardiology · 2012Article
- Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries.Clinical science (London, England : 1979) · 2011Article
- The anti-ischemic and anti-anginal properties of statins.Current atherosclerosis reports · 2011Review
- Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice.Biochemical and biophysical research communications · 2010Article
- Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- Lipid-independent pleiotropic effects of statins in the management of acute coronary syndromes.Current treatment options in cardiovascular medicine · 2007Article
- Endothelial dysfunction in diabetes mellitus.Vascular health and risk management · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHMG-CoA reductase inhibitors (statins) have been demonstrated to have in vitro vascular effects. The aim of this study was to determine whether statins actually have in vivo vascular effects independent of their cholesterol-lowering effect.
methodsWe investigated the effect of a single dose of cerivastatin on vascular endothelial function by measuring flow-mediated dilatation of the brachial artery on ultrasound in 30 healthy volunteers with normal serum cholesterol concentrations. They were randomized to either placebo group (n = 15) or cerivastatin group (n = 15), and flow-mediated dilatation and endothelium-dependent dilatation were evaluated at before and 1 h, 3 h, 6 h, and 12 h after administration of placebo or cerivastatin.
resultsThere were no differences in total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde-LDL, and high-sensitivity C-reactive protein before and after administration of placebo or cerivastatin. Cerivastatin significantly increased flow-mediated dilatation at 3 h (P < 0.001), and this increase rapidly returned to the baseline level 6 h after administration. Endothelium--independent dilatation of brachial artery was not altered.
conclusionsA single dose of cerivastatin increased vascular endothelial responsiveness. Our data suggest that cerivastatin has a direct effect on the blood vessels that is independent of its lipid-lowering effect, and thus can be considered as a vascular statin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.