ArticleVisual neuroscience
D2-like dopamine receptors promote interactions between calcium and chloride channels that diminish rod synaptic transfer in the salamander retina.
Article in Visual neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Differences in the Effect of Dopamine on the Phototransduction Between Lampreys and Jawed Vertebrates.International journal of molecular sciences · 2026Article
- The Role of the CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- Disturbed Presynaptic CaiScience · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- The effects of dopamine and dopamine receptor agonists on the phototransduction cascade of frog rods.Molecular vision · 2019Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors.The European journal of neuroscience · 2016Article
- Weak endogenous Ca2+ buffering supports sustained synaptic transmission by distinct mechanisms in rod and cone photoreceptors in salamander retina.Physiological reports · 2015Article
- Endogenous calcium buffering at photoreceptor synaptic terminals in salamander retina.Synapse (New York, N.Y.) · 2014Article
- Role of dopamine in distal retina.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Review
- Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.Frontiers in molecular neuroscience · 2014Review
- Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels.The Journal of general physiology · 2013Article
- Regulation of synaptic transmission at the photoreceptor terminal: a novel role for the cation-chloride co-transporter NKCC1.The Journal of physiology · 2013Article
- Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.PloS one · 2013Article
- Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system.Frontiers in physiology · 2012Article
- A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes.PloS one · 2012Article
- Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.Journal of neurophysiology · 2011Article
- Fast glutamate uptake via EAAT2 shapes the cone-mediated light offset response in bipolar cells.The Journal of physiology · 2010Article
- Calcium-induced calcium release contributes to synaptic release from mouse rod photoreceptors.Neuroscience · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Activation of D2-like dopamine receptors in rods with quinpirole stimulates L-type calcium currents (ICa). This result appears inconsistent with studies showing that D2-like dopamine receptor activation diminishes rod signals in second-order retinal neurons. Since small reductions in [Cl-] can inhibit photoreceptor ICa, we tested the hypothesis that enhancement of ICa with the D2/D4 receptor agonist, quinpirole, increases calcium-activated chloride currents (ICl(Ca)) causing an efflux of Cl- from rods that would provide a negative feedback inhibition of ICa. In agreement with studies from Xenopus, quinpirole reduced rod input to second-order neurons of tiger salamander retina without significantly altering rod voltage responses. Quinpirole also diminished the amplitude of depolarization-evoked increases in [Ca2+]i measured with Fura-2 in rods, a finding consistent with inhibition of synaptic transmission from rods. Electrophysiological and Cl(-)-imaging experiments indicated ECl in rods is approximately -20 mV. Quinpirole enhanced ICl(Ca) and elicited an efflux of Cl- at the resting potential. A similar Cl- efflux was produced by extracellular replacement of 24 mM Cl- with CH3SO4- and this low Cl- solution inhibited Ca2+ responses to a similar degree as quinpirole did. When ICl(Ca) was inhibited with niflumic acid, quinpirole enhanced both ICa and depolarization-evoked increases in [Ca2+]i. Furthermore, with niflumic acid, quinpirole no longer inhibited rod inputs into horizontal and bipolar cells. These results suggest an initial enhancement of ICa by quinpirole is followed by a stimulation of Cl- currents, including ICl(Ca). The net result is a Cl- efflux that inhibits depolarization-evoked increases in [Ca2+]i and synaptic transmission from rods.
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