ReviewMolecular neurobiology2002
Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain.
Review in Molecular neurobiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Preclinical Animal Models to Investigate the Role of NaLife (Basel, Switzerland) · 2025Review
- Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain.The journal of headache and pain · 2020Article
- Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.Experimental neurology · 2016Article
- Differing roles for parvalbumin neurons after nerve injury.Neural regeneration research · 2016Article
- TRPs and pain.Seminars in immunopathology · 2016Review
- Effects of peripheral nerve injury on parvalbumin expression in adult rat dorsal root ganglion neurons.BMC neuroscience · 2015Article
- Voltage-gated sodium channel expression in mouse DRG after SNI leads to re-evaluation of projections of injured fibers.Molecular pain · 2014Article
- Role of capsaicin-sensitive C-fiber afferents in neuropathic pain-induced synaptic potentiation in the nociceptive amygdala.Molecular pain · 2012Article
- Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain.Molecular pain · 2011Review
- Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions.The journal of pain · 2008Article
- Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.The Journal of clinical investigation · 2005Article
- Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
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Authors and funding
2 authors.
Funding
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Abstract
Neuropathic pain is caused by nervous-system lesions. Early studies on the pathomechanisms of this abnormal pain state have focused on the directly injured fibers and neurons. Here, we present recently accumulating data about the contribution of the primary afferent neurons spared from direct injury to the pathomechanisms of neuropathic pain. The phenotypic changes in the spared neurons are similar to those in the neurons in peripheral inflammation models, as opposed to those in the directly injured neurons. Electrophysiological changes and behavioral data also favor the contribution of the spared neurons. These attractive targets of study will give us new approaches for understanding the abnormal pain.
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