ArticleMolecular and cellular biology2002
Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 146 citations in OpenAlex.
- Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation.Nucleic acids research · 2025Article
- Enhancer-Mediated Formation of Nuclear Transcription Initiation Domains.International journal of molecular sciences · 2022Review
- Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.PLoS genetics · 2021Article
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation.Nature communications · 2020Article
- Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.PLoS genetics · 2020Article
- RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2.Nature communications · 2020Article
- Three classes of response elements for human PRC2 and MLL1/2-Trithorax complexes.Nucleic acids research · 2018Article
- Hierarchical recruitment of Polycomb complexes revisited.Nucleus (Austin, Tex.) · 2017Review
- HOXs and lincRNAs: Two sides of the same coin.Science advances · 2016Review
- Transcriptional read-through is not sufficient to induce an epigenetic switch in the silencing activity of Polycomb response elements.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transcription through Polycomb response elements does not induce a switch from repression to activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.Mechanisms of development · 2015Review
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- Hox gene regulation in the central nervous system of Drosophila.Frontiers in cellular neuroscience · 2014Review
- Article
- Long noncoding RNAs as metazoan developmental regulators.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- A genetic approach to the recruitment of PRC2 at the HoxD locus.PLoS genetics · 2013Article
- The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila.Development (Cambridge, England) · 2013Article
- Polycomb group response elements in Drosophila and vertebrates.Advances in genetics · 2013Review
- RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proteins of the trithorax and Polycomb groups maintain the differential expression pattern of homeotic genes established by the early embryonic patterning system during development. These proteins generate stable and heritable chromatin structures by acting via particular chromosomal memory elements. We established a transgenic assay system showing that the Polycomb group response elements bxd and Mcp confer epigenetic inheritance throughout development. With previously published data for the Fab7 cellular memory module, we confirmed the cellular memory function of Polycomb group response elements. In Drosophila melanogaster, several of these memory elements are located in the large intergenic regulatory regions of the homeotic bithorax complex. Using a transgene assay, we showed that transcription through a memory element correlated with the relief of silencing imposed by the Polycomb group proteins and established an epigenetically heritable active chromatin mode. A memory element remodeled by the process of transcription was able to maintain active expression of a reporter gene throughout development. Thus, transcription appears to reset and change epigenetic marks at chromosomal memory elements regulated by the Polycomb and trithorax proteins. Interestingly, in the bithorax complex of D. melanogaster, the segment-specific expression of noncoding intergenic transcripts during embryogenesis seems to fulfill this switching role for memory elements regulating the homeotic genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.