ArticleMolecular and cellular biology2002
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 171 citations in OpenAlex.
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- Heat Shock Proteins and HSF1 in Cancer.Frontiers in oncology · 2022Review
- Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects.International journal of molecular sciences · 2021Review
- Genomewide identification and analysis of heat-shock proteins 70/110 to reveal their potential functions in Chinese soft-shelled turtleEcology and evolution · 2019Article
- Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage.Molecular neurobiology · 2018Article
- ASK family in cardiovascular biology and medicine.Advances in biological regulation · 2017Review
- Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.Cancer growth and metastasis · 2017Article
- HSP70 in human polymorphonuclear and mononuclear leukocytes: comparison of the protein content and transcriptional activity of HSPA genes.Cell stress & chaperones · 2017Article
- Targeting Hsp70: A possible therapy for cancer.Cancer letters · 2016Review
- Up-regulation of Hsp72 and keratin16 mediates wound healing in streptozotocin diabetic rats.Biological research · 2015Article
- Role of membrane Hsp70 in radiation sensitivity of tumor cells.Radiation oncology (London, England) · 2015Article
- Heat shock proteins in neurodegenerative disorders and aging.Journal of cell communication and signaling · 2014Article
- Heat-shock protein 70 modulates apoptosis signal-regulating kinase 1 in stressed hepatocytes of Mugil cephalus.Fish physiology and biochemistry · 2014Article
- Genome-wide identification of heat shock proteins (Hsps) and Hsp interactors in rice: Hsp70s as a case study.BMC genomics · 2014Article
- Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.Cardiovascular research · 2014Article
- Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.Cell death & disease · 2014Article
- The complex function of hsp70 in metastatic cancer.Cancers · 2013Article
- Maternal embryonic leucine zipper kinase (MELK): a novel regulator in cell cycle control, embryonic development, and cancer.International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock protein 72 (Hsp72) is thought to protect cells against cellular stress. The protective role of Hsp72 was investigated by determining the effect of this protein on the stress-activated protein kinase signaling pathways. Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). Overexpression of Hsp72 also inhibited H(2)O(2)-induced activation of ASK1 as well as that of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade. Recombinant Hsp72 bound directly to ASK1 and inhibited ASK1 activity in vitro. Furthermore, coimmunoprecipitation analysis revealed a physical interaction between endogenous Hsp72 and ASK1 in NIH 3T3 cells exposed to mild heat shock. Hsp72 blocked both the homo-oligomerization of ASK1 and ASK1-dependent apoptosis. Hsp72 antisense oligonucleotides prevented the inhibitory effects of mild heat shock on H(2)O(2)-induced ASK1 activation and apoptosis. These observations suggest that Hsp72 functions as an endogenous inhibitor of ASK1.
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