ArticleJournal of applied physiology (Bethesda, Md. : 1985)2002
Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.British journal of pharmacology · 2023Article
- Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth.Growth factors (Chur, Switzerland) · 2020Article
- Basic Fibroblast Growth Factor Attenuates Injury in Myocardial Infarction by Enhancing Hypoxia-Inducible Factor-1 Alpha Accumulation.Frontiers in pharmacology · 2020Article
- Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.American journal of physiology. Heart and circulatory physiology · 2013Article
- Transplantation of bone marrow derived monocytes: a novel approach for augmentation of arteriogenesis in a murine model of femoral artery ligation.American journal of translational research · 2013Article
- Microvascular repair: post-angiogenesis vascular dynamics.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Structural remodeling of the mouse gracilis artery: coordinated changes in diameter and medial area maintain circumferential stress.Microcirculation (New York, N.Y. : 1994) · 2012Article
- Exercise training and peripheral arterial disease.Comprehensive Physiology · 2012Review
- Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery.Journal of vascular research · 2012Article
- Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery.American journal of physiology. Heart and circulatory physiology · 2011Article
- Chronic hindlimb ischemia impairs functional vasodilation and vascular reactivity in mouse feed arteries.Frontiers in physiology · 2011Article
- Implanted microvessels progress through distinct neovascularization phenotypes.Microvascular research · 2010Article
- Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way.Nature reviews. Clinical oncology · 2009Review
- Gene targeted ablation of high molecular weight fibroblast growth factor-2.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- A modified fluorescent microsphere-based approach for determining resting and hyperemic blood flows in individual murine skeletal muscles.Vascular pharmacology · 2007Article
- Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2).British journal of pharmacology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ischemic revascularization involves extensive structural adaptation of the vasculature, including both angiogenesis and arteriogenesis. Previous studies suggest that fibroblast growth factor (FGF)-2 participates in both angiogenesis and arteriogenesis. Despite this, the specific role of endogenous FGF-2 in vascular adaptation during ischemic revascularization is unknown. Therefore, we used femoral artery ligation in Fgf2(+/+) and Fgf2(-/-) mice to test the hypothesis that endogenous FGF-2 is an important regulator of angiogenesis and arteriogenesis in the setting of hindlimb ischemia. Femoral ligation increased capillary and arteriole density in the ischemic calf in both Fgf2(+/+) and Fgf2(-/-) mice. The level of angiographically visible arteries in the thigh was increased in the ischemic hindlimb in all mice, and no significant differences were observed between Fgf2(+/+) and Fgf2(-/-) mice. Additionally, limb perfusion progressively improved to peak values at day 35 postsurgery in both genotypes. Given the equivalent responses observed in Fgf2(+/+) and Fgf2(-/-) mice, we demonstrate that endogenous FGF-2 is not required for revascularization in the setting of peripheral ischemia. Vascular adaptation, including both angiogenesis and arteriogenesis, was not affected by the absence of FGF-2 in this model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.