ArticleClinical and experimental immunology2002
The role of anti-endothelial cell antibodies in Kawasaki disease - in vitro and in vivo studies.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Serological distribution of anti-endothelial cell antibodies and their association with laboratory indicators in autoimmune and immune-mediated diseases.Clinical rheumatology · 2025Article
- Anti-endothelial cell antibodies in pathogenesis of vasculitis.Frontiers in immunology · 2025Review
- Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19.Frontiers in immunology · 2023Article
- Article
- Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq.bioRxiv : the preprint server for biology · 2022Article
- Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison.Nature reviews. Rheumatology · 2021Review
- Association Between Kawasaki Disease and Childhood Epilepsy: A Nationwide Cohort Study in Taiwan.Frontiers in neurology · 2021Article
- Article
- Multisystem inflammatory syndrome in children: Is there a linkage to Kawasaki disease?Trends in cardiovascular medicine · 2020Review
- Antibodies and Immunity During Kawasaki Disease.Frontiers in cardiovascular medicine · 2020Review
- B Cells and Antibodies in Kawasaki Disease.International journal of molecular sciences · 2019Review
- Coronary artery ectasia in Crohn's disease.BMJ case reports · 2018Article
- How Should We Classify Kawasaki Disease?Frontiers in immunology · 2018Review
- Kawasaki Disease Increases the Incidence of Myopia.BioMed research international · 2017Article
- Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease.Drug discovery today · 2016Review
- Triptolide as an Alternative to IVIG Therapy for Kawasaki Disease in a Mouse Model.Balkan medical journal · 2013Article
- Elevated Serum Levels of IL-21 in Kawasaki Disease.Allergy, asthma & immunology research · 2012Article
- Autoantibodies in systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2012Review
- Increased frequency of immunoglobulin (Ig)A-secreting cells following Toll-like receptor (TLR)-9 engagement in patients with Kawasaki disease.Clinical and experimental immunology · 2011Article
- Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin.Autoimmunity reviews · 2010Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is a systemic vasculitis with cardiac and noncardiac complications. Anti--endothelial cell antibodies (AECA) are found among many patients with KD. The aim of this study was to investigate the pathogenic role of AECA in KD using in vitro and in vivo experimental models. F(ab)2 fragments of IgG-AECA and IgM-AECA were affinity purified from a patient with active KD. Their endothelial binding and ability to induce a pro-adhesive and a pro-inflammatory phenotype were evaluated in vitro. Twenty Balb/C mice were immunized with KD-AECA or with control Ig (N-Ig) to induce AECA in a murine model by the idiotypic manipulation method. Both KD-AECA isotypes bind significantly to human umbilical vein endothelial cell (HUVEC) compared to N-Ig. The in vitro activity was demonstrated by the antibodies ability to activate endothelial cells resulting in increased IL-6 secretion, adhesion molecule expression and monocytic cell line (U937) adherence to HUVEC. Five of the mice that received KD-AECA developed murine AECA after 3 months. None of the mice that received N-Ig produced AECA. The murine AECA increased monocyte adhesion to EC in vitro, similarly to the AECA used for immunization. Furthermore, all the mice that developed AECA had proteinuria and IgG deposition in the renal mesangium. No histological or immunofluorescence evidence of cardiac vasculitis could be detected. AECA might play a role in the emergence of some of KD manifestations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.