ArticleProceedings of the National Academy of Sciences of the United States of America2002
Isolation and characterization of lymphocyte-like cells from a lamprey.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 141 citations in OpenAlex.
- LampreyProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution.Nature communications · 2024Article
- Article
- Which came first, T cells or B cells?Nature reviews. Immunology · 2021Article
- Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages.Cells · 2021Review
- The Evolution of Rag Gene Enhancers and Transcription Factor E and Id Proteins in the Adaptive Immune System.International journal of molecular sciences · 2021Review
- The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system.Immunogenetics · 2021Review
- Co-evolution of mutagenic genome editors and vertebrate adaptive immunity.Current opinion in immunology · 2020Review
- Innate immunological memory: from plants to animals.Current opinion in immunology · 2020Review
- Cell circuits and niches controlling B cell development.Immunological reviews · 2019Review
- Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans.Molecular and cellular biology · 2017Article
- Evolution of two prototypic T cell lineages.Cellular immunology · 2015Article
- Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury.Experimental neurology · 2014Review
- Cloning and expression analysis of a novel high-mobility group box 2 homologue from Lampetra japonica.Fish physiology and biochemistry · 2014Article
- Evolutionary conservation of divergent pro-inflammatory and homeostatic responses in Lamprey phagocytes.PloS one · 2014Article
- Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease.Matrix biology : journal of the International Society for Matrix Biology · 2013Article
- Changing views of the evolution of immunity.Frontiers in immunology · 2013Article
- The vigor of defense against non-self: potential superiority of allorestricted T cells in immunotherapy of cancer?Frontiers in oncology · 2013Article
- The research of W.E. Mayer (1953-2012): a spectrum of immune systems.Immunogenetics · 2012Review
- Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen.Infectious disorders drug targets · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphocyte-like cells in the intestine of the sea lamprey, Petromyzon marinus, were isolated by flow cytometry under light-scatter conditions used for the purification of mouse intestinal lymphocytes. The purified lamprey cells were morphologically indistinguishable from mammalian lymphocytes. A cDNA library was prepared from the lamprey lymphocyte-like cells, and more than 8,000 randomly selected clones were sequenced. Homology searches comparing these ESTs with sequences deposited in the databases led to the identification of numerous genes homologous to those predominantly or characteristically expressed in mammalian lymphocytes, which included genes controlling lymphopoiesis, intracellular signaling, proliferation, migration, and involvement of lymphocytes in innate immune responses. Genes closely related to those that in gnathostomes control antigen processing and transport of antigenic peptides could be ascertained, although no sequences with significant similarity to MHC, T cell receptor, or Ig genes were found. The data suggest that the evolution of lymphocytes in the lamprey has reached a stage poised for the emergence of adaptive immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.