ArticleMolecular biology of the cell2002
Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin.Cancer research · 2019Article
- Article
- Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility.The Journal of reproduction and development · 2017Article
- Two Geminin homologs regulate DNA replication in silkworm, Bombyx mori.Cell cycle (Georgetown, Tex.) · 2017Article
- Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility.Molecular biology of the cell · 2016Article
- Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements.PLoS genetics · 2014Article
- Regulating DNA replication in eukarya.Cold Spring Harbor perspectives in biology · 2013Review
- Genomic instability in cancer.Cold Spring Harbor perspectives in biology · 2013Review
- Cdc6 is required for meiotic spindle assembly in Xenopus oocytes.Cell cycle (Georgetown, Tex.) · 2012Article
- Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.PloS one · 2012Article
- Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.Development (Cambridge, England) · 2012Article
- Article
- Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.The Journal of biological chemistry · 2011Article
- S-phase-coupled apoptosis in tumor suppression.Cellular and molecular life sciences : CMLS · 2011Review
- Geminin-deficient neural stem cells exhibit normal cell division and normal neurogenesis.PloS one · 2011Article
- NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells.Cancer research · 2010Article
- Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice.The Journal of clinical investigation · 2010Article
- Life without geminin.Cell cycle (Georgetown, Tex.) · 2010Article
- Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.The Journal of biological chemistry · 2009Article
- Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.Molecular biology of the cell · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Geminin is an unstable inhibitor of DNA replication that gets destroyed at the metaphase/anaphase transition. The biological function of geminin has been difficult to determine because it is not homologous to a characterized protein and has pleiotropic effects when overexpressed. Geminin is thought to prevent a second round of initiation during S or G2 phase. In some assays, geminin induces uncommitted embryonic cells to differentiate as neurons. In this study, geminin was eliminated from developing Xenopus embryos by using antisense techniques. Geminin-deficient embryos show a novel and unusual phenotype: they complete the early cleavage divisions normally but arrest in G2 phase immediately after the midblastula transition. The arrest requires Chk1, the effector kinase of the DNA replication/DNA damage checkpoint pathway. The results indicate that geminin has an essential function and that loss of this function prevents entry into mitosis by a Chk1-dependent mechanism. Geminin may be required to maintain the structural integrity of the genome or it may directly down-regulate Chk1 activity. The data also show that during the embryonic cell cycles, rereplication is almost entirely prevented by geminin-independent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.