Evidence map›Paper›PMID 12388740›Full record

ArticleJournal of virology2002

Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein.

Charles R Madden, Milton J Finegold, Betty L Slagle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  8. Update in global trends and aetiology of hepatocellular carcinoma.Contemporary oncology (Poznan, Poland) · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Charles R MaddenDepartment of Molecular Virology and Microbiology. Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Milton J Finegold
Betty L Slagle
Baylor College of Medicine · US

Funding

Research Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4M
HEPATITIS B VIRUS AND HEPATOCELLULAR CARCINOMAR01CA054557 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SLAGLE, BETTY L · 1991 to 1999
–
NCI NIH HHS CA54557NIDDK NIH HHS T32 DK007664NIDDK NIH HHS T32DK07664
6 · The paper itself

Abstract

Humans chronically infected with hepatitis B virus (HBV) are at further risk of liver cancer upon exposure to dietary aflatoxin B1 (AFB1), a carcinogenic product of the mold Aspergillus flavus. For the present study, we utilized double-transgenic mice (ATX mice) that express the HBV X protein (HBx) and possess a bacteriophage lambda transgene to evaluate the in vivo effect of HBx expression on AFB1-induced DNA mutations. The expression of HBx correlated with a 24% increase in mutation frequency overall and an approximately twofold increase in the incidence of G/C-to-T/A transversion mutations following AFB1 exposure. These results are consistent with a model in which expression of HBx during chronic HBV infection may contribute to the development of hepatocellular carcinoma following exposure to environmental carcinogens.

Indexed as

MutationAflatoxin B1AnimalsBacteriophage lambdaCarcinoma, HepatocellularDNAFemaleHepatitis B, ChronicMaleMiceMice, Inbred C57BLMice, Inbred ICRMice, TransgenicTrans-ActivatorsTransgenesViral Regulatory and Accessory ProteinsAflatoxin B1DNAhepatitis B virus X proteinTrans-ActivatorsViral Regulatory and Accessory Proteins

Identifiers

PMID12388740
PMCPMC136763
OpenAlexW2110422744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.