ArticleJournal of virology2002
Characterization of porcine endogenous retrovirus gamma pro-pol nucleotide sequences.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Surveillance and prevention of infection in clinical xenotransplantation.Clinical microbiology reviews · 2025Review
- Infection in xenotransplantation: opportunities and challenges.Current opinion in organ transplantation · 2019Review
- Polymorphic integrations of an endogenous gammaretrovirus in the mule deer genome.Journal of virology · 2012Article
- Evolution of endogenous retroviruses in the Suidae: evidence for different viral subpopulations in African and Eurasian host species.BMC evolutionary biology · 2011Article
- Identification and classification of endogenous retroviruses in cattle.Journal of virology · 2008Article
- Porcine endogenous retrovirus integration sites in the human genome: features in common with those of murine leukemia virus.Journal of virology · 2006Article
- Isolation and characterization of an infectious replication-competent molecular clone of ecotropic porcine endogenous retrovirus class C.Journal of virology · 2006Article
- Reliable classification and recombination analysis of porcine endogenous retroviruses.Virus genes · 2005Article
- Evidence and consequence of porcine endogenous retrovirus recombination.Journal of virology · 2004Article
- Determinants of high titer in recombinant porcine endogenous retroviruses.Journal of virology · 2004Article
- Xenotransplantation: infectious risk revisited.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2004Review
- Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine.Journal of virology · 2004Article
- Characterization of endogenous retroviruses in sheep.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous retroviral sequences in the pig genome (PERV) represent a potential infectious risk in xenotransplantation. All known infectious PERV have been asssigned to the PERV gamma1 family, consisting of the subfamilies A, B, and C. The aim of the study was the concise examination of PERV gamma by the analysis of the retroviral pro-pol sequences. The analysis of 52 pro-pol clones amplified in this study revealed eight PERV gamma families. In addition to four already-described families (gamma1, gamma4, gamma5, gamma6), four novel families (gamma7, gamma8, gamma9, gamma10) were identified. Quantitative analysis of the novel PERV gamma sequences in selected breeds revealed variations in the endogenous retroviral load. Open reading frames (ORF) in the amplified proviral fragment were only found for PERV gamma1. In addition, novel ORF-containing PERV gamma1 clones consisting of hybrid sequences were revealed. Sequence comparison from published full-length PERV gamma1 clones of the PERV subfamilies A, B, and C resulted in a lack of strict correlation of the classification of pro-pol and env. The results indicated the occurrence of causative recombination events between retroviral genomes. Thus, our study on PERV gamma provides new data for the evaluation and selection of pigs intended to be used in xenotransplantation.
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