ArticleJournal of virology2002
Regulation of bovine papillomavirus replicative helicase e1 by the ubiquitin-proteasome pathway.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Current status and future directions for the development of human papillomavirus vaccines.Frontiers in immunology · 2024Review
- Novel Antigenic Targets of HPV Therapeutic Vaccines.Vaccines · 2021Review
- Design and Immunological Validation ofFrontiers in immunology · 2021Article
- Activity of CK2α protein kinase is required for efficient replication of some HPV types.PLoS pathogens · 2019Article
- Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.Journal of virology · 2015Article
- The role of ubiquitin and ubiquitin-like modification systems in papillomavirus biology.Viruses · 2014Review
- The E1 proteins.Virology · 2013Review
- Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers.Biology of the cell · 2012Review
- Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.Virology · 2009Article
- Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication.Journal of virology · 2007Article
- Mitogen-activated protein kinases activate the nuclear localization sequence of human papillomavirus type 11 E1 DNA helicase to promote efficient nuclear import.Journal of virology · 2007Article
- Genomic instability of the host cell induced by the human papillomavirus replication machinery.The EMBO journal · 2007Article
- Nuclear import of bovine papillomavirus type 1 E1 protein is mediated by multiple alpha importins and is negatively regulated by phosphorylation near a nuclear localization signal.Journal of virology · 2007Article
- Nucleocytoplasmic shuttling of bovine papillomavirus E1 helicase downregulates viral DNA replication in S phase.Journal of virology · 2007Article
- A phosphorylation map of the bovine papillomavirus E1 helicase.Virology journal · 2006Article
- Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein.Virology · 2005Article
- Bovine papillomavirus replicative helicase E1 is a target of the ubiquitin ligase APC.Journal of virology · 2004Article
- Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papillomaviruses maintain their genomes in a relatively constant copy number as stable extrachromosomal plasmids in the nuclei of dividing host cells. The viral initiator of replication, E1, is not detected in papillomavirus-infected cells. Here, we present evidence that E1 encoded by bovine papillomavirus type 1 is an unstable protein that is degraded through the ubiquitin-proteasome pathway. In a cell-free system derived from Xenopus egg extracts, E1 degradation is regulated by both cyclin E/Cdk2 binding and E1 replication activity. Free E1 is readily ubiquitinated and degraded by the proteasome, while it becomes resistant to this degradation pathway when bound to cyclin E/Cdk2 complexes before the start of DNA synthesis. This stabilization is reversed in a process involving E1-dependent replication activity. In transiently transfected cells, E1 is also polyubiquitinated and accumulates when proteasome activity is inhibited. Thus, the establishment and maintenance of a stable number of papillomavirus genomes in latently infected cells are in part a function of regulated ubiquitin-mediated degradation of E1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.