ArticleGenetic epidemiology2002
Increase in power of transmission-disequilibrium tests for quantitative traits.
Article in Genetic epidemiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Molecular genetic studies of complex phenotypes.Translational research : the journal of laboratory and clinical medicine · 2012Review
- Family-based association study of ROR2 polymorphisms with an array of radiographic hand bone strength phenotypes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2007Article
- Strong association between polymorphisms in ANKH locus and skeletal size traits.Human genetics · 2006Article
- Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population.Arthritis research & therapy · 2005Article
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Authors and funding
3 authors.
Funding
Abstract
Allison ([1997] Am. J. Hum. Genet. 60:676-690) proposed four versions of the transmission-disequilibrium test (TDT) for quantitative traits when there is extreme-threshold sampling, i.e., the trios having an offspring trait value between a priori defined thresholds are excluded from the analysis. Keeping intact the ideology and construction of these tests, we propose here an extreme-offspring design for the trios: for each parent pair of which at least one is heterozygous at a marker locus, the offspring having the most extreme trait value is selected for the trio. Our simulation studies show that the effect of the extreme-offspring design can be quite substantial (up to 30% increase in test power), and that the increase is greater for smaller values of the association parameter and for traits with smaller heritability: just those cases where the increase in power is especially desirable.
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Registered trials
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