ArticleAmerican journal of human genetics2002
Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
188 citing papers in PubMed.
- A Study of Single Nucleotide Polymorphisms of the SLC19A1/RFC1 Gene in Subjects with Autism Spectrum Disorder.International journal of molecular sciences · 2016Trial
- Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.Proceedings of the National Academy of Sciences of the United States of America · 2006Trial
- The impact of sample size and marker selection on the study of haplotype structures.Human genomics · 2004Trial
- Efficiency under epistasis of haplotype-based genomic selection for pure line breeding.Heredity · 2026Article
- Standardized microhaplotype databases and frameworks for assessing and mining crop genetic diversity.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Constitution and function of intergenic genome regions in cultivated versus annual wild soybean in China.Journal of integrative plant biology · 2026Article
- Haplotype applications in genomic selection.Genome biology · 2026Review
- Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Network analysis combined with genome-wide association study helps identification of genes related to amino acid contents in soybean.BMC genomics · 2025Article
- Article
- Genome-Wide Association Study for Resistance toPlants (Basel, Switzerland) · 2024Article
- Genetic dissection of resistance to Phytophthora sojae using genome-wide association and linkage analysis in soybean [Glycine max (L.) Merr.].TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Molecular genetic diversity and linkage disequilibrium structure of the Egyptian faba bean using Single Primer Enrichment Technology (SPET).BMC genomics · 2024Article
- Genomic prediction within and across maize landrace derived populations using haplotypes.Frontiers in plant science · 2024Article
- Genetic diversity, linkage disequilibrium, and population structure of tetraploid wheat landraces originating from Europe and Asia.BMC genomics · 2023Article
- Evaluation of Density-Based Spatial Clustering for Identifying Genomic Loci Associated with Ischemic Stroke in Genome-Wide Data.International journal of molecular sciences · 2023Article
- Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity.Pediatric research · 2023Article
- Uniparental Inheritance and Recombination as Strategies to Avoid Competition and Combat Muller's Ratchet among Mitochondria in Natural Populations of the FungusJournal of fungi (Basel, Switzerland) · 2023Article
- CandiHap: a haplotype analysis toolkit for natural variation study.Molecular breeding : new strategies in plant improvement · 2023Article
- SNP- and haplotype-based single-step genomic predictions for body weight, wool, and reproductive traits in North American Rambouillet sheep.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2023Article
128 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest that haplotypes are arranged into discrete blocklike structures throughout the human genome. Here, we present an alternative haplotype block definition that assumes no recombination within each block but allows for recombination between blocks, and we use it to study the combined effects of demographic history and various population genetic parameters on haplotype block characteristics. Through extensive coalescent simulations and analysis of published haplotype data on chromosome 21, we find that (1) the combined effects of population demographic history, recombination, and mutation dictate haplotype block characteristics and (2) haplotype blocks can arise in the absence of recombination hot spots. Finally, we provide practical guidelines for designing and interpreting studies investigating haplotype block structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.