ArticleNucleic acids research2002
Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma.Frontiers in immunology · 2026Article
- The up-regulation of TGF-β1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages.PloS one · 2025Article
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- Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration.Histochemistry and cell biology · 2017Article
- Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells.Nucleus (Austin, Tex.) · 2017Article
- p130Cas acts as survival factor during PMA-induced apoptosis in HL-60 promyelocytic leukemia cells.The international journal of biochemistry & cell biology · 2013Article
- The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation.Molecular biology of the cell · 2012Article
- Macrophage-dependent cleavage of the laminin receptor α6β1 in prostate cancer.Molecular cancer research : MCR · 2011Article
- The possible functions of duplicated ets (GGAA) motifs located near transcription start sites of various human genes.Cellular and molecular life sciences : CMLS · 2011Article
- Role of host cell polarity and leading edge properties in Pseudomonas type III secretion.Microbiology (Reading, England) · 2010Article
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- Binding of the Streptococcus gordonii DL1 surface protein Hsa to the host cell membrane glycoproteins CD11b, CD43, and CD50.Infection and immunity · 2008Article
- Effects of cardiotonic steroids on dermal collagen synthesis and wound healing.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Translocation of heparanase into nucleus results in cell differentiation.Cancer science · 2007Article
- MEK-ERK is involved in SUMO-1 foci formation on apoptosis.Cancer science · 2007Article
- PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells.Gene expression · 2006Article
- Current awareness on comparative and functional genomics.Comparative and functional genomics · 2003Article
- Application of DNA microarrays in pharmacogenomics and toxicogenomics.Pharmaceutical research · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent inducer of differentiation in human promyelocytic leukemia cells. Recently, TPA has been successfully administered to patients with myelocytic leukemia and has produced therapeutic effects that led to temporary remission. These studies demonstrated the potential efficacy of TPA in cancer chemotherapy. We now seek to understand the biological effects and molecular mechanisms of differentiation in response to TPA treatment in leukemia cells by expression profiling using DNA microarray. Our results show distinct temporal and coordinated gene changes that are consistent with differentiation and activation of multiple biochemical pathways in HL-60 cells exposed to TPA. Alterations of gene expression in HL-60 cells include various transcription factors, cytokines and protein markers that are consistent with the induction of differentiation elicited by TPA. These temporal patterns of gene expression were abolished or greatly diminished in an HL-60 derived TPA- resistant variant cell line (HL-525), thus revealing transcriptional and consequential biochemical changes that may be required for TPA-induced differentiation. In addition, certain genes were upregulated by TPA in TPA-resistant HL-525 cells but not in TPA-sensitive HL-60 cells suggesting that these genes may play a role in the resistant phenotype. These patterns of gene expression may be important for predicting response to TPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.