ArticleNucleic acids research2002
A PIWI homolog is one of the proteins expressed exclusively during macronuclear development in the ciliate Stylonychia lemnae.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches.Science China. Life sciences · 2025Article
- The Sac10b homolog from Sulfolobus islandicus is an RNA chaperone.Nucleic acids research · 2020Article
- Review
- Transformation with Artificial Chromosomes inG3 (Bethesda, Md.) · 2019Article
- 27nt-RNAs guide histone variant deposition via 'RNA-induced DNA replication interference' and thus transmit parental genome partitioning in Stylonychia.Epigenetics & chromatin · 2018Article
- Article
- Differential expression of histone H3 genes and selective association of the variant H3.7 with a specific sequence class in Stylonychia macronuclear development.Epigenetics & chromatin · 2014Article
- A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation.Epigenetics & chromatin · 2013Article
- ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation.Molecular biology of the cell · 2011Article
- Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery.PloS one · 2011Article
- Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development.PLoS pathogens · 2010Article
- Histone modifications are specifically relocated during gene activation and nuclear differentiation.BMC genomics · 2009Article
- Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development.Epigenetics & chromatin · 2008Article
- Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma.Oncogene · 2007Article
- Differential gene expression during stationary phase between amicronucleates and micronucleates of the ciliated protist, Pseudourostyla cristata.Current genetics · 2005Article
- snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates.Eukaryotic cell · 2005Article
- The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism.Genome biology · 2003Article
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3 authors.
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Abstract
In the course of macronuclear differentiation in spirotrichous ciliates massive DNA reorganization processes take place, which include splicing, cutting, rearranging and eliminating specific DNA sequences. In order to identify genes involved in these processes we took advantage of suppression subtractive hybridization. We have identified three transcripts that are exclusively expressed during macronuclear development in the ciliate Stylonychia lemnae. Two of the three differentially expressed mRNAs we have analyzed encode for novel proteins. One gene, mdp1 [macronuclear development protein 1 (MDP1)], encodes a homolog of the PIWI protein family. PIWI proteins are involved in germline differentiation processes and RNA silencing in worms, flies, mice, humans and in plants. Possible functions of the S.lemnae PIWI related protein MDP1 in the regulation of macronuclear development will be discussed.
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