ArticleProceedings of the National Academy of Sciences of the United States of America2002
Expanding protein universe and its origin from the biological Big Bang.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- On the Origin of Biomolecular Networks.Frontiers in genetics · 2019Pooled it
- In silico evolution of globular protein folds from random sequences.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolving concepts of the protein universe.iScience · 2025Review
- Reused Protein Segments Linked to Functional Dynamics.Molecular biology and evolution · 2024Article
- A review of visualisations of protein fold networks and their relationship with sequence and function.Biological reviews of the Cambridge Philosophical Society · 2023Review
- Protein folds as synapomorphies of the tree of life.Evolution; international journal of organic evolution · 2022Article
- Genetic networks encode secrets of their past.Journal of theoretical biology · 2022Article
- Bridging Themes: Short Protein Segments Found in Different Architectures.Molecular biology and evolution · 2021Article
- Experimentally-driven protein structure modeling.Journal of proteomics · 2020Review
- Article
- Size and structure of the sequence space of repeat proteins.PLoS computational biology · 2019Article
- ProteomeVis: a web app for exploration of protein properties from structure to sequence evolution across organisms' proteomes.Bioinformatics (Oxford, England) · 2018Article
- The scale-free nature of protein sequence space.PloS one · 2018Article
- Complex evolutionary footprints revealed in an analysis of reused protein segments of diverse lengths.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Biophysical journal · 2017Article
- Exploring the dark foldable proteome by considering hydrophobic amino acids topology.Scientific reports · 2017Article
- Size distribution of function-based human gene sets and the split-merge model.Royal Society open science · 2016Article
- Structural Bridges through Fold Space.PLoS computational biology · 2015Article
- Functional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same Gene.The Journal of biological chemistry · 2015Article
- A new method to improve network topological similarity search: applied to fold recognition.Bioinformatics (Oxford, England) · 2015Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
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Abstract
The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.
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Registered trials
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