Evidence map›Paper›PMID 12384374›Full record

ArticleAntimicrobial agents and chemotherapy2002

Propranolol inhibits hyphal development in Candida albicans.

Carol A Baker, Kevin Desrosiers, Joseph W Dolan

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Propranolol is efficacious againstAntimicrobial agents and chemotherapy · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Carol A BakerDepartment of Microbiology & Immunology. Department of Stomatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Kevin Desrosiers
Joseph W Dolan
Medical University of South Carolina · USNortheastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propranolol was used to investigate the role of phosphatidic acid (PA) and diacylglycerol in the dimorphic transition in Candida albicans. Propranolol was able to inhibit the appearance of germ tubes without decreasing growth rate. Data suggest that inhibition of morphogenesis may be due to binding by propranolol of PA derived from PLD1 hydrolysis of phosphatidylcholine.

Indexed as

Antifungal AgentsAdrenergic beta-AntagonistsAnimalsCandida albicansCells, CulturedDiglyceridesHumansPhosphatidic AcidsPhospholipase DPropranololAdrenergic beta-AntagonistsAntifungal AgentsDiglyceridesPhosphatidic AcidsPhospholipase Dphospholipase D1Propranolol

Identifiers

PMID12384374
PMCPMC128717
OpenAlexW2155722759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.