ArticleBMC psychiatry2002
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].
Article in BMC psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Organisational interventions for preventing and minimising aggression directed towards healthcare workers by patients and patient advocates.The Cochrane database of systematic reviews · 2020Pooled it
- Aripiprazole (intramuscular) for psychosis-induced aggression or agitation (rapid tranquillisation).The Cochrane database of systematic reviews · 2018Pooled it
- Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation).The Cochrane database of systematic reviews · 2017Pooled it
- Haloperidol plus promethazine for psychosis-induced aggression.The Cochrane database of systematic reviews · 2016Pooled it
- Containment strategies for people with serious mental illness.The Cochrane database of systematic reviews · 2006Pooled it
- Clotiapine for acute psychotic illnesses.The Cochrane database of systematic reviews · 2004Pooled it
- Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine.BMJ (Clinical research ed.) · 2003Trial
- Management of Antenatal Agitation in a Tertiary Care Center in Central India: A Secondary Analysis.Cureus · 2024Article
- Article
- Comparison of Haloperidol, Promethazine, Trifluoperazine, and Chlorpromazine in Terms of Velocity and Durability of the Sedation among Acute Aggressive Patients: A Randomized Clinical Trial.Advanced biomedical research · 2019Article
- Benzodiazepines for psychosis-induced aggression or agitation.The Cochrane database of systematic reviews · 2017Review
- Prescribing preferences in rapid tranquillisation: a survey in Belgian psychiatrists and emergency physicians.BMC research notes · 2015Article
- Has research informed us on the practical drug treatment of schizophrenia?Schizophrenia bulletin · 2008Article
- Unanswered questions in schizophrenia clinical trials.Schizophrenia bulletin · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAgitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ. Systematic reviews show that all relevant studies are small and none are likely to have adequate power to show true differences between treatments. Worldwide, current treatment is not based on evidence from randomised trials. In Brazil, the combination haloperidol-promethazine is frequently used, but no studies involving this mix exist.
methodsTREC-Rio (Tranquilização Rápida-Ensaio Clínico [Translation: Rapid Tranquillisation-Clinical Trial]) will compare midazolam with haloperidol-promethazine mix for treatment of agitated patients in emergency psychiatric rooms of Rio de Janeiro, Brazil. TREC-Rio is a randomised, controlled, pragmatic and open study. Primary measure of outcome is tranquillisation at 20 minutes but effects on other measures of morbidity will also be assessed. TREC-Rio will involve the collaboration of as many health care professionals based in four psychiatric emergency rooms of Rio as possible. Because the design of this trial does not substantially complicate clinical management, and in several aspects simplifies it, the study can be large, and treatments used in everyday practice can be evaluated.
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