ArticleThe Journal of physiology2002
Characterization of the A-type potassium current in murine gastric antrum.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- CaCell calcium · 2021Article
- Characterization of the A-type potassium current in murine gastric fundus smooth muscles.American journal of physiology. Cell physiology · 2021Article
- Low-voltage-activated inward current in murine antral smooth muscle cells is an artifact.American journal of physiology. Cell physiology · 2021Article
- Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Computational motility models of neurogastroenterology and neuromodulation.Brain research · 2018Review
- Modelling Human Colonic Smooth Muscle Cell Electrophysiology.Cellular and molecular bioengineering · 2017Article
- Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.American journal of physiology. Cell physiology · 2011Article
- Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II.Archives of biochemistry and biophysics · 2011Review
- CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.Neurogastroenterology and motility · 2010Article
- Citrobacter rodentium colitis evokes post-infectious hyperexcitability of mouse nociceptive colonic dorsal root ganglion neurons.The Journal of physiology · 2009Article
- Modulation of murine gastric antrum smooth muscle STOC activity and excitability by phospholamban.The Journal of physiology · 2008Article
- Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes.British journal of pharmacology · 2006Article
- Effect of genistein on voltage-gated potassium channels in guinea pig proximal colon smooth muscle cells.World journal of gastroenterology · 2006Article
- A-type potassium current in retinal arteriolar smooth muscle cells.Investigative ophthalmology & visual science · 2005Article
- Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current.The Journal of physiology · 2003Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A-type currents are rapidly inactivating potassium currents that operate at subthreshold potentials. A-type currents have not been reported to occur in the phasic muscles of the stomach. We used conventional voltage-clamp techniques to identify and characterize A-type currents in myocytes isolated from the murine antrum. A-type currents were robust in these cells, with peak current densities averaging 30 pA pF(-1) at 0 mV. These currents underwent rapid inactivation with a time constant of 83 ms at 0 mV. Recovery from inactivation at -80 mV was rapid, with a time constant of 252 ms. The A-type current was blocked by 4-aminopyridine (4-AP) and was inhibited by flecainide, with an IC(50) of 35 microM. The voltage for half-activation was -26 mV, while the voltage of half-inactivation was -65 mV. There was significant activation and incomplete inactivation at potentials positive to -60 mV, which is suggestive of sustained current availability in this voltage range. Under current-clamp conditions, exposure to 4-AP or flecainide depolarized the membrane potential by 7-10 mV. In intact antral tissue preparations, flecainide depolarized the membrane potential between slow waves by 5 mV; changes in slow waves were not evident. The effect of flecainide was not abolished by inhibiting enteric neurotransmission or by blocking delayed rectifier and ATP-sensitive K(+) currents. Transcripts encoding Kv4 channels were detected in isolated antral myocytes by RT-PCR. Immunocytochemistry revealed intense Kv4.2- and Kv4.3-like immunoreactivity in antral myocytes. These data suggest that the A-type current in murine antral smooth muscle cells is likely to be due to Kv4 channels. This current contributes to the maintenance of negative resting membrane potentials.
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