ArticleThe Journal of physiology2002
Characterization of K(+) currents using an in situ patch clamp technique in body wall muscle cells from Caenorhabditis elegans.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 30 citations in OpenAlex.
- Early characterization of excitation-contraction coupling and SLO-2 channel properties inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells.Chemical science · 2020Article
- KNeuroscience · 2020Article
- c302: a multiscale framework for modelling the nervous system ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Review
- Physiological regulation of the epithelial NaAmerican journal of physiology. Renal physiology · 2018Article
- A Gustatory Neural Circuit ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Emodepside and SL0-1 potassium channels: a review.Experimental parasitology · 2012Review
- Oxidation of a potassium channel causes progressive sensory function loss during aging.Nature neuroscience · 2009Article
- Three types of single voltage-dependent potassium channels in the sarcolemma of frog skeletal muscle.The Journal of membrane biology · 2009Article
- ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1.Traffic (Copenhagen, Denmark) · 2008Article
- A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.PLoS biology · 2008Article
- SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics.Invertebrate neuroscience : IN · 2007Review
- Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans.The Journal of biological chemistry · 2006Article
- CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx.The Journal of experimental biology · 2005Article
- An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells.The Journal of physiology · 2004Article
- Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle.The Journal of physiology · 2004Article
- Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans.The Journal of cell biology · 2002Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The properties of K(+) channels in body wall muscle cells acutely dissected from the nematode Caenorhabditis elegans were investigated at the macroscopic and unitary level using an in situ patch clamp technique. In the whole-cell configuration, depolarizations to potentials positive to -40 mV gave rise to outward currents resulting from the activation of two kinetically distinct voltage-dependent K(+) currents: a fast activating and inactivating 4-aminopyridine-sensitive component and a slowly activating and maintained tetraethylammonium-sensitive component. In cell-attached patches, voltage-dependent K(+) channels, with unitary conductances of 34 and 80 pS in the presence of 5 and 140 mM external K(+), respectively, activated at membrane potentials positive to -40 mV. Excision revealed that these channels corresponded to Ca(2+)-activated K(+) channels exhibiting an unusual sensitivity to internal Cl(-) and whose activity progressively decreased in inside-out conditions. After complete run-down of these channels, one third of inside-out patches displayed activity of another Ca(2+)-activated K(+) channel of smaller unitary conductance (6 pS at 0 mV in the presence of 5 mM external K(+)). In providing a detailed description of native K(+) currents in body wall muscle cells of C. elegans, this work lays the basis for further comparisons with mutants to assess the function of K(+) channels in this model organism that is highly amenable to molecular and classical genetics.
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