ArticleProceedings of the National Academy of Sciences of the United States of America2002
The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.Nature communications · 2021Trial
- Context-specific functions of chromatin remodellers in development and disease.Nature reviews. Genetics · 2024Review
- Deletion ofInternational journal of molecular sciences · 2021Article
- Prenatal modulation of breast density and breast stem cells by insulin-like growth factor-1.American journal of stem cells · 2012Article
- Systems biology beyond networks: generating order from disorder through self-organization.Seminars in cancer biology · 2011Review
- The two faces of Janus kinases and their respective STATs in mammary gland development and cancer.Journal of carcinogenesis · 2011Article
- The contribution of adhesion signaling to lactogenesis.Journal of cell communication and signaling · 2010Article
- Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Theories of carcinogenesis: an emerging perspective.Seminars in cancer biology · 2008Review
- Emergentism as a default: cancer as a problem of tissue organization.Journal of biosciences · 2005Review
- Prolactin effect on pre-pubertal Sertoli cell proliferation and metabolism.Journal of endocrinological investigation · 2003Article
- Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function.Journal of mammary gland biology and neoplasia · 2003Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The cytokine hormones prolactin and erythropoietin mediate tissue-specific developmental outcomes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR), respectively. The EpoR is essential for red blood cell formation, whereas a principal function of PrlR is in the development of the mammary gland during pregnancy and lactation [Ormandy, C., et al. (1997) Genes Dev. 11, 167-178]. The instructive model of differentiation proposes that such distinct, cytokine-dependent developmental outcomes are a result of cytokine receptor-unique signals that bring about induction of lineage-specific genes. This view was challenged by our finding that an exogenously expressed PrlR could rescue EpoR(-/-) erythroid progenitors and mediate their differentiation into red blood cells. Together with similar findings in other hematopoietic lineages, this suggested that cytokine receptors do not play an instructive role in hematopoietic differentiation. Here, we show that these findings are not limited to the hematopoietic system but are of more general relevance to cytokine-dependent differentiation. We demonstrate that the developmental defect of PrlR(-/-) mammary epithelium is rescued by an exogenously expressed chimeric receptor (prl-EpoR) containing the PrlR extracellular domain joined to the EpoR transmembrane and intracellular domains. Like the wild-type PrlR, the prl-EpoR rescued alveologenesis and milk secretion in PrlR(-/-) mammary epithelium. These results suggest that, in cell types as unrelated as erythrocytes and mammary epithelial cells, cytokine receptors employ similar, generic signals that permit the expression of predetermined, tissue-specific differentiation programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.