ArticleBritish journal of pharmacology2002
Role of the platelet-activating factor (PAF) receptor during pulmonary infection with gram negative bacteria.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Platelet Activating Factor Receptor and Intercellular Adhesion Molecule-1 Expression Increases in the Small Airway Epithelium and Parenchyma of Patients with Idiopathic Pulmonary Fibrosis: Implications for Microbial Pathogenesis.Journal of clinical medicine · 2024Article
- Associations of phase angle with platelet-activating factor metabolism and related dietary factors in healthy volunteers.Frontiers in nutrition · 2023Article
- Platelet-Activating Factor as an Effector for Environmental Stressors.Handbook of experimental pharmacology · 2020Article
- TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium.Mucosal immunology · 2019Article
- Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice.Antimicrobial agents and chemotherapy · 2018Article
- Characterization of the Phospholipid Platelet-Activating Factor As a Mediator of Inflammation in Chickens.Frontiers in veterinary science · 2017Article
- Influence of platelet-activating factor receptor (PAFR) on Brucella abortus infection: implications for manipulating the phagocytic strategy of B. abortus.BMC microbiology · 2016Article
- Platelet-activating factor receptor blockade ameliorates Aggregatibacter actinomycetemcomitans-induced periodontal disease in mice.Infection and immunity · 2013Article
- Pneumonia-induced sepsis in mice: temporal study of inflammatory and cardiovascular parameters.International journal of experimental pathology · 2013Article
- Microbial modulation of host immunity with the small molecule phosphorylcholine.Infection and immunity · 2013Review
- Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis.Hepatology (Baltimore, Md.) · 2011Article
- Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis.Immunology · 2008Article
- The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza.Scandinavian journal of infectious diseases · 2008Article
- Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.The American journal of pathology · 2006Article
- Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium.Infection and immunity · 2006Article
- Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression.British journal of pharmacology · 2005Article
- Impaired host defense to Klebsiella pneumoniae infection in mice treated with the PDE4 inhibitor rolipram.British journal of pharmacology · 2003Article
- Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw.British journal of pharmacology · 2003Article
- Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment.British journal of pharmacology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lipid mediator PAF plays an important role in the phagocytosis of particles, including bacteria, and consequent production of pro-inflammatory cytokines, such as TNF-alpha and IL-8. Using a PAF receptor antagonist (UK-74,505) and PAF receptor knock-out mice, we have investigated the relevance of PAF for the inflammatory changes and lethality after pulmonary infection with the gram-negative bacteria Klebsiella pneumoniae in mice. At an inoculum of 3 x 10(6) bacteria, there was marked pulmonary (bronchoalveolar lavage and lung) neutrophilia that started early (2.5 h after infection) and peaked at 48 h. All animals were dead by day 4 of infection. The chemokine KC and the pro-inflammatory cytokine TNF-alpha increased rapidly and persisted for 48 h in the lungs. Pretreatment with UK-74,505 (30 mg kg(-1) per day, p.o.) had no significant effects on the number of infiltrating neutrophils in BAL fluid or lung tissue, as assessed by histology and measuring myeloperoxidase, or on the concentrations of KC. In contrast, concentrations of TNF-alpha and the number of bacteria inside neutrophils were significantly diminished. In order to support a role for the PAF during K. pneumoniae infection, experiments were also carried out in PAFR-deficient mice. In the latter animals, lethality occurred earlier than in wild-type controls. This was associated with greater number of bacteria in lung tissue and diminished percentage of neutrophils containing bacteria in their cytoplasm. Our results suggest that PAF, acting on its receptor, plays a protective role during infection with K. pneumoniae in mice.
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