ArticleGenes & development2002
A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungusVirulence · 2022Article
- Early patterning followed by tissue growth establishes distal identity inFrontiers in cell and developmental biology · 2022Article
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation.Nature communications · 2020Article
- Three classes of response elements for human PRC2 and MLL1/2-Trithorax complexes.Nucleic acids research · 2018Article
- Hierarchical recruitment of Polycomb complexes revisited.Nucleus (Austin, Tex.) · 2017Review
- Review
- The legacy of Drosophila imaginal discs.Chromosoma · 2016Review
- Article
- On Having No Head: Cognition throughout Biological Systems.Frontiers in psychology · 2016Review
- Transcription through Polycomb response elements does not induce a switch from repression to activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration.Development (Cambridge, England) · 2015Article
- Article
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- A genetic approach to the recruitment of PRC2 at the HoxD locus.PLoS genetics · 2013Article
- Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression.Molecular and cellular biology · 2013Article
- Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin.Nucleic acids research · 2013Article
- Polycomb group response elements in Drosophila and vertebrates.Advances in genetics · 2013Review
- Adaptation or malignant transformation: the two faces of epigenetically mediated response to stress.BioMed research international · 2013Review
- Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation.Nature reviews. Molecular cell biology · 2012Review
- Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.Immunity · 2012Article
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2 authors.
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Abstract
In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins interact with chromosomal elements, termed Cellular Memory Modules (CMMs). By modifying chromatin, this ensures a stable heritable maintenance of the transcriptional state of developmental regulators, like the homeotic genes, that is defined embryonically. We asked whether such CMMs could also control expression of genes involved in patterning imaginal discs during larval development. Our results demonstrate that expression of the hedgehog gene, once activated, is maintained by a CMM. In addition, our experiments indicate that the switching of such CMMs to an active state during larval stages, in contrast to embryonic stages, may require specific trans-activators. Our results suggest that the patterning of cells in particular developmental fields in the imaginal discs does not only rely on external cues from morphogens, but also depends on the previous history of the cells, as the control by CMMs ensures a preformatted gene expression pattern.
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