ArticleGenes & development2002
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 115 citations in OpenAlex.
- Role of PER-WDR5 interactions in the mammalian circadian clock.Nature communications · 2026Article
- Inferring regulators of cell identity in the human adult pancreas.NAR genomics and bioinformatics · 2023Article
- Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.International journal of molecular sciences · 2023Review
- Induction of internal circadian desynchrony by misaligning zeitgebers.Scientific reports · 2022Article
- Differentiating external zeitgeber impact on peripheral circadian clock resetting.Scientific reports · 2019Article
- Decanalizing thinking on genetic canalization.Seminars in cell & developmental biology · 2019Review
- Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b.Cell reports · 2018Article
- F-spondin Is Essential for Maintaining Circadian Rhythms.Frontiers in neural circuits · 2018Article
- Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.Cell · 2017Article
- Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Emerging models for the molecular basis of mammalian circadian timing.Biochemistry · 2015Review
- The Mammalian circadian clock gene per2 modulates cell death in response to oxidative stress.Frontiers in neurology · 2014Article
- Loss of circadian clock gene expression is associated with tumor progression in breast cancer.Cell cycle (Georgetown, Tex.) · 2014Article
- Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range.Journal of the Royal Society, Interface · 2013Article
- Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cry1-/- circadian rhythmicity depends on SCN intercellular coupling.Journal of biological rhythms · 2012Article
- Integration of the circadian and stress systems: influence of neuropeptides and implications for alcohol consumption.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- Identification of a novel cryptochrome differentiating domain required for feedback repression in circadian clock function.The Journal of biological chemistry · 2012Article
- Klf15 orchestrates circadian nitrogen homeostasis.Cell metabolism · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many biochemical, physiological, and behavioral processes display daily rhythms generated by an internal timekeeping mechanism referred to as the circadian clock. The core oscillator driving this clock is located in the ventral part of the hypothalamus, the so called suprachiasmatic nuclei (SCN). At the molecular level, this oscillator is thought to be composed of interlocking autoregulatory feedback loops involving a set of clock genes. Among the components driving the mammalian circadian clock are the Period 1 and 2 (mPer1 and mPer2) and Cryptochrome 1 and 2 (mCry1 and mCry2) genes. A mutation in the mPer2 gene leads to a gradual loss of circadian rhythmicity in mice kept in constant darkness (DD). Here we show that inactivation of the mCry2 gene in mPer2 mutant mice restores circadian rhythmicity and normal clock gene expression patterns. Thus, mCry2 can act as a nonallelic suppressor of mPer2, which points to direct or indirect interactions of PER2 and CRY2 proteins. In marked contrast, inactivation of mCry1 in mPer2 mutant mice does not restore circadian rhythmicity but instead results in complete behavioral arrhythmicity in DD, indicating different effects of mCry1 and mCry2 in the clock mechanism
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.