ArticleGenes & development2002
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 182 citations in OpenAlex.
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- Context-dependent synthetic lethality - an emerging precision therapeutic approach.Nature reviews. Cancer · 2026Review
- Lipid Metabolism in Relation to Carbohydrate Metabolism.Advances in experimental medicine and biology · 2026Review
- UsingCells · 2023Review
- A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms.Development (Cambridge, England) · 2022Article
- Drosophila Sirtuin 6 mediates developmental diet-dependent programming of adult physiology and survival.Aging cell · 2022Article
- Review
- Differential metabolic sensitivity of insulin-like-response- and TORC1-dependent overgrowth in Drosophila fat cells.Genetics · 2021Article
- A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.Molecular genetics and genomics : MGG · 2019Article
- AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration.Cell death & disease · 2019Article
- A Drosophila Based Cancer Drug Discovery Framework.Advances in experimental medicine and biology · 2019Review
- FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction.PLoS genetics · 2018Article
- The Target of Rapamycin and Mechanisms of Cell Growth.International journal of molecular sciences · 2018Review
- Twenty-five years of mTOR: Uncovering the link from nutrients to growth.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.Nature communications · 2017Article
- Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila.Cell reports · 2017Article
- The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function.PLoS genetics · 2016Article
- Article
- Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase.Journal of cellular and molecular medicine · 2015Article
- Regulation of mTORC1 by PI3K signaling.Trends in cell biology · 2015Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in one of two tumor suppressor genes, TSC1 and TSC2. Here, we show that absence of Drosophila Tsc1/2 leads to constitutive dS6K activation and inhibition of dPKB, the latter effect being relieved by loss of dS6K. In contrast, the dPTEN tumor suppressor, a negative effector of PI3K, has little effect on dS6K, but negatively regulates dPKB. More importantly, we demonstrate that reducing dS6K signaling rescues early larval lethality associated with loss of dTsc1/2 function, arguing that the S6K pathway is a promising target for the treatment of TSC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.