ReviewCell stress & chaperones2002
Growing old with nuclear factor-kappaB.
Review in Cell stress & chaperones, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Renin-angiotensin system inhibitors positively impact on multiple aging regulatory pathways: Could they be used to protect against human aging?Physiological reports · 2024Review
- Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models.Cells · 2021Review
- The role of astrocytes in amyloid production and Alzheimer's disease.Open biology · 2017Review
- Saponins fromNeural regeneration research · 2017Article
- Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB.Scientific reports · 2016Article
- NF-κB inhibition delays DNA damage-induced senescence and aging in mice.The Journal of clinical investigation · 2012Article
- Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging.Mechanisms of ageing and development · 2012Article
- NF-κB in Aging and Disease.Aging and disease · 2011Article
- Characteristics of lymphocyte nuclear factor-κB signal transduction kinase expression in aging process and regulatory effect of epimedium flavonoids.Chinese journal of integrative medicine · 2011Article
- Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity.Journal of experimental & clinical cancer research : CR · 2011Article
- NF-kappaB signaling in the aging process.Journal of clinical immunology · 2009Article
- Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan.The international journal of biochemistry & cell biology · 2008Review
- Tissue specific and non-specific changes in gene expression by aging and by early stage CR.Mechanisms of ageing and development · 2006Article
- Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival.Molecular and cellular biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor nuclear factor-kappa B (NF-kappaB) is involved in the regulation of a broad spectrum of genes that play important roles in a myriad of physiological and pathological events ranging from the immune response to carcinogenesis. Interestingly, many processes in which NF-kappa B plays a central role have long been noted for their alteration with age. A number of research groups have reported rather dramatic changes in NF-kappaB activity as humans and animals age, with tissue-specific increases and decreases in NF-kappaB activity being reported. The extent to which changes in NF-kappaB activity drive aging and influence life span in humans and other mammals is not clear. However, given the dramatic impact that NF-kappaB can have on the function of numerous tissues and organs, understanding how NF-kappaB activity changes with age will undoubtedly enhance our understanding of the many diseases associated with growing old.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.