ReviewCell stress & chaperones2002
Activation of the mitogen-activated protein kinase pathways by heat shock.
Review in Cell stress & chaperones, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 96 citations in OpenAlex.
- Single-cell profiling of glial cells from the mouse amygdala under opioid dependent and withdrawal states.iScience · 2023Article
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- Peroxiredoxin-6 regulates p38-mediated epithelial-mesenchymal transition in HCT116 colon cancer cells.Journal of biological research (Thessalonike, Greece) · 2021Article
- Environmental Factors That Contribute to the Maintenance ofMicroorganisms · 2020Review
- Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model.International journal of ophthalmology · 2020Article
- Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17.International journal of molecular sciences · 2018Article
- Genomewide association analyses of fitness traits in captive-reared Chinook salmon: Applications in evaluating conservation strategies.Evolutionary applications · 2018Article
- An investigation of methyl tert‑butyl ether‑induced cytotoxicity and protein profile in Chinese hamster ovary cells.Molecular medicine reports · 2017Article
- HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2017Article
- Whole genome sequencing of Guzerá cattle reveals genetic variants in candidate genes for production, disease resistance, and heat tolerance.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis.Research in veterinary science · 2016Article
- Article
- Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.Cell host & microbe · 2015Article
- A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.Genes & development · 2014Article
- Article
- Function of the p38MAPK-HSP27 pathway in rat lung injury induced by acute ischemic kidney injury.BioMed research international · 2013Article
- Article
- Heat shock proteins modulate keloid formation.Eplasty · 2011Article
- Diphosphoinositol polyphosphates: what are the mechanisms?Advances in enzyme regulation · 2011Review
- Activation of the CMV-IE promoter by hyperthermia in vitro and in vivo: biphasic heat induction of cytosine deaminase suicide gene expression.Molecular biotechnology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to inducing new transcriptional activities that lead within a few hours to the accumulation of heat shock proteins (Hsps), heat shock activates within minutes the major signaling transduction pathways involving mitogen-activated protein kinases, extracellular signal-regulated kinase, stress-activated protein kinase 1 (SAPK1)-c-Jun N-terminal kinase, and SAPK2-p38. These kinases are involved in both survival and death pathways in response to other stresses and may, therefore, contribute significantly to the heat shock response. In the case of p38, the activation leads to the phosphorylation and activation of one of the Hsps, Hsp27. Phosphorylation occurs very early during stress, is tightly regulated, and results from the triggering of a highly specific heat shock-sensing pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.