ReviewHeart failure reviews2002
NO and the vasculature: where does it come from and what does it do?
Review in Heart failure reviews, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.Scientific reports · 2020Article
- Hyperglycemia-Induced Changes in Hyaluronan Contribute to Impaired Skin Wound Healing in Diabetes: Review and Perspective.International journal of cell biology · 2015Review
- Melanopsin mediates light-dependent relaxation in blood vessels.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Hydrodynamic regulation of lymphatic transport and the impact of aging.Pathophysiology : the official journal of the International Society for Pathophysiology · 2010Article
- Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species.Free radical biology & medicine · 2009Article
- Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.American journal of physiology. Heart and circulatory physiology · 2008Article
- Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- Computational modeling of factors that modulate the unique FeNO bonding in {FeNO}(6) heme-thiolate model complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2007Article
- Pharmacologic modulators of soluble guanylate cyclase/cyclic guanosine monophosphate in the vascular system - from bench top to bedside.Current vascular pharmacology · 2007Review
- Contraction-initiated NO-dependent lymphatic relaxation: a self-regulatory mechanism in rat thoracic duct.The Journal of physiology · 2006Article
- Nitric oxide in heart failure: friend or foe.Heart failure reviews · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is involved in a large number of cellular processes and dysfunctions in NO production have been implicated in many different disease states. In the vasculature NO is released by endothelial cells where it modulates the underlying smooth muscle to regulate vascular tone. Due to the unique chemistry of NO, such as its reactive and free radical nature, it can interact with many different cellular constituents such as thiols and transition metal ions, which determine its cellular actions. In this review we also discuss many of the useful pharmacological tools that have been developed and used extensively to establish the involvement of NO in endothelium-derived relaxations. In addition, the recent literature identifying a potential source of NO in endothelial cells, which is not directly derived from endothelial nitric oxide synthase is examined. Finally, the photorelaxation phenomena, which mediates the release of NO from a vascular smooth muscle NO store, is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.