ArticleInfection and immunity2002
Babesia bovis merozoite surface antigen 2 proteins are expressed on the merozoite and sporozoite surface, and specific antibodies inhibit attachment and invasion of erythrocytes.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Cross-species therapeutics in Plasmodium and Babesia: erythrocyte invasion and conserved drug targets.Tropical animal health and production · 2026Review
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- Spherical Body Protein 4 fromPathogens (Basel, Switzerland) · 2023Article
- Transmission Cycle of Tick-Borne Infections and Co-Infections, Animal Models and Diseases.Pathogens (Basel, Switzerland) · 2022Review
- Plasmepsin-like Aspartyl Proteases inPathogens (Basel, Switzerland) · 2021Article
- A framework for signaling throughout the life cycle of Babesia species.Molecular microbiology · 2021Review
- Characterization of the variable merozoite surface antigen (VMSA) gene family of Babesia orientalis.Parasitology research · 2020Article
- Genetic Diversity ofPathogens (Basel, Switzerland) · 2020Article
- Surface Antigen 1 Is a Crucial Secreted Protein That MediatesFrontiers in microbiology · 2019Article
- Evaluation of a Major Surface Antigen ofFrontiers in microbiology · 2017Article
- The genetic diversity of merozoite surface antigen 1 (MSA-1) among Babesia bovis detected from cattle populations in Thailand, Brazil and Ghana.The Journal of veterinary medical science · 2013Article
- Transmission and epidemiology of zoonotic protozoal diseases of companion animals.Clinical microbiology reviews · 2013Review
- The invasion process of bovine erythrocyte by Babesia divergens: knowledge from an in vitro assay.Veterinary research · 2011Article
- Transovarial transmission efficiency of Babesia bovis tick stages acquired by Rhipicephalus (Boophilus) microplus during acute infection.Journal of clinical microbiology · 2007Article
- The Babesia bovis merozoite surface antigen 1 hypervariable region induces surface-reactive antibodies that block merozoite invasion.Infection and immunity · 2006Article
- Merozoite surface antigen 2 proteins of Babesia bovis vaccine breakthrough isolates contain a unique hypervariable region composed of degenerate repeats.Infection and immunity · 2005Article
- Sequence variation and immunologic cross-reactivity among Babesia bovis merozoite surface antigen 1 proteins from vaccine strains and vaccine breakthrough isolates.Infection and immunity · 2005Article
- Babesia divergens and Plasmodium falciparum use common receptors, glycophorins A and B, to invade the human red blood cell.Infection and immunity · 2005Article
- Conservation of Babesia bovis small heat shock protein (Hsp20) among strains and definition of T helper cell epitopes recognized by cattle with diverse major histocompatibility complex class II haplotypes.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Babesia bovis merozoite surface antigen 2 (MSA-2) locus encodes four proteins, MSA-2a(1), -2a(2), -2b, and -2c. With the use of specific antibodies, each MSA-2 protein was shown to be expressed on the surface of live extracellular merozoites and coexpression on single merozoites was confirmed. Individual antisera against MSA-2a, MSA-2b, and MSA-2c significantly inhibited merozoite invasion of bovine erythrocytes. As tick-derived sporozoites also directly invade erythrocytes, expression of each MSA-2 protein on the sporozoite surface was examined and verified. Finally, statistically significant inhibition of sporozoite binding to the erythrocytes was demonstrated by using antisera specific for MSA-2a, MSA-2b, and MSA-2c. These results indicate an important role for MSA-2 proteins in the initial binding and invasion of host erythrocytes and support the hypothesis that sporozoites and merozoites use common surface molecules in erythrocyte invasion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.