ArticleInfection and immunity2002
Infection with Strongyloides venezuelensis induces transient airway eosinophilic inflammation, an increase in immunoglobulin E, and hyperresponsiveness in rats.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Measurement of MPO, NAG, and EPO as an Indirect Quantification of Leukocyte Infiltration in Mouse Tissues.Methods in molecular biology (Clifton, N.J.) · 2026Article
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- Helminth infections affect host immune responses to viral infections and vaccines.FEMS microbiology reviews · 2025Review
- The Th2 Response and Alternative Activation of Macrophages Triggered byJournal of fungi (Basel, Switzerland) · 2023Article
- Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections.Cell · 2021Article
- Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice.PLoS pathogens · 2021Article
- A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome.Microbiome · 2021Article
- Sequential Changes in the Host Gut Microbiota During Infection With the Intestinal Parasitic NematodeFrontiers in cellular and infection microbiology · 2019Article
- Fatal strongyloidiasis after corticosteroid therapy for presumed chronic obstructive pulmonary disease.JMM case reports · 2018Article
- IgE and mast cells in host defense against parasites and venoms.Seminars in immunopathology · 2016Review
- The role of IL-33/ST2, IL-4, and eosinophils on the airway hyperresponsiveness induced by Strongyloides venezuelensis in BALB/c mice.Parasitology research · 2016Article
- Acute and chronic exposure to Tyrophagus putrescentiae induces allergic pulmonary response in a murine model.Asia Pacific allergy · 2016Article
- Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice.PLoS neglected tropical diseases · 2016Article
- Effect of different stages of Schistosoma mansoni infection on the parasite burden and immune response to Strongyloides venezuelensis in co-infected mice.Parasitology research · 2015Article
- Trichinella spiralis: killing of newborn larvae by lung cells.Parasitology research · 2015Article
- Effect of low-level laser therapy on allergic asthma in rats.Lasers in medical science · 2014Article
- Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice.Infection and immunity · 2004Article
- Regulation of allergy and autoimmunity in helminth infection.Clinical reviews in allergy & immunology · 2004Review
- Changes in pulmonary function and parasite burden in rats infected with Strongyloides venezuelensis concomitant with induction of allergic airway inflammation.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection by nematode parasites with a pulmonary migration in their life cycle and allergic asthma are two highly prevalent diseases in humans; therefore, one may expect both may occur concomitantly. There is a predominant and essential role of Th2 lymphocytes in the mechanisms underlying the control of parasite elimination as well as in the pathology observed in the asthmatic lung. The consequences of such situations have been explored, with controversial results, justifying the development of experimental models in which the relationship between allergic airway inflammation and helminth infection might be evaluated. The present work describes the inflammatory, humoral, and functional changes that occur in the lung of rats after single (subcutaneous inoculation of 1,500 L3 larvae) or multiple (five weekly subcutaneous inoculations of 1,500 L3 larvae) Strongyloides venezuelensis infections. The results show that the migration of S. venezuelensis larvae through the lungs of infected rats induces a local eosinophilic inflammation process which is mostly focal and parenchymal for rats infected a single time and which is peribronchial after multiple infections. The inflammatory process is accompanied by mucus hypersecretion, thickening of bronchial epithelial and muscle layers, and local increase in immunoglobulin E concentrations that peak after 5 to 7 days and are resolved after 12 days of single or multiple infections. The peak of lung immunopathologic changes observed in infected rats coincides with lung airway hyperresponsiveness (AHR), a key functional alteration in asthma. We propose that this experimental model is ideal to carry out further studies on immunoprotection against nematode infection versus immunopathology of allergic airway inflammation.
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