ReviewAnnals of the rheumatic diseases2002
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Review in Annals of the rheumatic diseases, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD.European journal of nutrition · 2010Trial
- Article
- Nanotechnology-driven strategies for gene therapy of arthritis.Materials today. Bio · 2025Review
- Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells.Inflammopharmacology · 2019Article
- miR-410-3p Suppresses Cytokine Release from Fibroblast-Like Synoviocytes by Regulating NF-κB Signaling in Rheumatoid Arthritis.Inflammation · 2019Article
- Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network.Frontiers in genetics · 2019Article
- Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin.International journal of inflammation · 2018Review
- Therapeutic effects of matrine derivate MASM in mice with collagen-induced arthritis and on fibroblast-like synoviocytes.Scientific reports · 2017Article
- Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression.Scientific reports · 2016Article
- Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.World journal of orthopedics · 2014Review
- Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells.American journal of translational research · 2014Review
- Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects.Frontiers in cell and developmental biology · 2014Article
- Novel insights into the regulatory architecture of CD4+ T cells in rheumatoid arthritis.PloS one · 2014Article
- Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.The American journal of pathology · 2013Article
- Binding of NF-κB to nucleosomes: effect of translational positioning, nucleosome remodeling and linker histone H1.PLoS genetics · 2013Article
- Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.PloS one · 2012Article
- Article
- Effects of hyaluronan on carrageenan-induced synovitis in rat TMJ.Anatomy & cell biology · 2010Article
- High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations.Rheumatology international · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.