Evidence map›Paper›PMID 12379578›Full record

ArticleCirculation2002

Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?

Kennedy Cruickshank, Lisa Riste, Simon G Anderson, John S Wright, Graham Dunn, Ray G Gosling

Registry-linked trialAbstract read
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In one paragraph

Article in Circulation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03355469 (Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome), which is not on this map. Cited by 496 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
496citing papers in PubMed, 5 pooled it
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355469 phase2 / phase3completedstarted 2017, after this paper: background citation

Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Ran2017Enrolled91Registered outcomes6Posted comparisons36ConditionsMetabolic SyndromeArmsHigh intensity exercise, Low intensity exercise, Metformin, Placebo
PMID 26583801PMID 11300445PMID 22040838PMID 16115299PMID 23505172PMID 17785362PMID 12677025PMID 12767663PMID 16644702PMID 16682488PMID 18340209PMID 18606913other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

496 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,515 citations in OpenAlex.

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436 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kennedy CruickshankClinical Epidemiology Group, School of Epidemiology & Health Sciences, University of Manchester Medical School, Manchester, UK. clinep@man.ac.uk
Lisa Riste
Simon G Anderson
John S Wright
Graham Dunn
Ray G Gosling
Northwick Park Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArterial distensibility measures, generally from pulse-wave velocity (PWV), are widely used with little knowledge of relationships to patient outcome. We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples. METHODS AND

resultsParticipants were randomly sampled from (1) a type 2 diabetes outpatient clinic and (2) primary care population registers, from which nondiabetic control subjects were given a GTT. Brachial blood pressures and Doppler-derived aortic PWV were measured. Mortality data over 10 years' follow-up were obtained. At any level of systolic blood pressure (SBP), aortic PWV was greater in subjects with diabetes than in controls. Mortality risk doubled in subjects with diabetes (hazard ratio 2.34, 95% CI 1.5 to 3.74) and in those with glucose intolerance (2.12, 95% CI 1.11 to 4.0) compared with controls. For all groups combined, age, sex, and SBP predicted mortality; the addition of PWV independently predicted all-cause and cardiovascular mortality (hazard ratio 1.08, 95% CI 1.03 to 1.14 for each 1 m/s increase) but displaced SBP. Glucose tolerance status and smoking were other independent contributors, with African-Caribbeans experiencing reduced mortality risk (hazard ratio 0.41, 95% CI 0.25 to 0.69).

conclusionsAortic PWV is a powerful independent predictor of mortality in both diabetes and GTT population samples. In displacing SBP as a prognostic factor, aortic PWV is probably further along the causal pathway for arterial disease and may represent a useful integrated index of vascular status and hence cardiovascular risk.

Indexed as

AortaBlood PressureCardiovascular DiseasesComplianceDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlucose IntoleranceGlucose Tolerance TestHumansMaleMiddle AgedPrognosisRandom AllocationRisk FactorsSurvival Rate

Identifiers

PMID12379578
OpenAlexW2071010874

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.