ArticleAnnals of the rheumatic diseases2002
Infectious background of patients with a history of acute anterior uveitis.
Article in Annals of the rheumatic diseases, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Pertussis toxin-induced inhibition of Wnt/β-catenin signaling in dendritic cells promotes an autoimmune response in experimental autoimmune uveitis.Journal of neuroinflammation · 2023Article
- Article
- A Novel Clinical Five-Risk Factor Panel for Individualized Recurrence Risk Assessment of Patients With Acute Anterior Uveitis.Translational vision science & technology · 2021Article
- Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis.Frontiers in medicine · 2018Article
- The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status.Frontiers in immunology · 2018Article
- Commensal microbiota as a potential trigger of autoimmune uveitis.Expert review of clinical immunology · 2017Article
- The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis.PloS one · 2015Article
- Emerging role of antioxidants in the protection of uveitis complications.Current medicinal chemistry · 2011Review
- [Ocular involvement in spondyloarthropathies: HLA B27 associated uveitis].Zeitschrift fur Rheumatologie · 2010Review
- HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations.Clinical microbiology reviews · 2004Review
- The role of Vitamin D in immuno-inflammatory responses in Ankylosing Spondylitis patients with and without Acute Anterior Uveitis.Journal of medicine and lifeArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the infectious background of patients with a history of acute anterior uveitis (AAU) and healthy control subjects.
methodsSixty four patients with previous AAU and 64 sex and age matched controls were studied. Serum antibodies to Salmonellae, Yersiniae, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Campylobacter jejuni, and Borrelia burgdorferi were measured using enzyme linked immunosorbent assay (ELISA), and antibodies to Chlamydia trachomatis and Chlamydia pneumoniae by microimmunofluorescence test. Peripheral blood mononuclear cells (PBMCs), separated by density gradient centrifugation, were studied for Salmonella and Yersinia antigens by means of an immunofluorescence test, and for C pneumoniae DNA with a polymerase chain reaction (PCR).
resultsNeither prevalence nor levels of single microbial antibodies studied differed between the patients and control subjects, or between subgroups of patients created on the basis of clinical characteristics. In logistic regression analysis, the high number of recurrences (>10) of AAU was independently related to the presence of single or multiple bacterial antibodies (p=0.04). None of the PBMC samples of the patients were positive for Yersinia or Salmonella antigens. C pneumoniae PCR was positive in a patient who was negative for C pneumoniae antibodies.
conclusionAlthough neither the prevalence nor the levels of single microbial antibodies studied differed between the patients and the controls, current data suggest that the presence of single or multiple antibodies in patients with many recurrences of AAU compared with patients with none or few recurrences may be a sign of repeated infections, antigen persistence, or raised innate immune responsiveness.
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