ArticleBMC cancer2002
Predominance of CIN versus MSI in the development of rectal cancer at young age.
Article in BMC cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Rectal Cancer: Exploring Predictive Biomarkers Through Molecular Pathways Involved in Carcinogenesis.Biology · 2024Review
- Diverging likelihood of colon and rectal cancer in Yogyakarta, Indonesia: A cross sectional study.PloS one · 2024Article
- Distinct Molecular Profiles of Sporadic Early-Onset Colorectal Cancer: A Population-Based Cohort and Systematic Review.Gastro hep advances · 2023Review
- Increased Levels of Genomic Instability and Mutations in Homologous Recombination Genes in Locally Advanced Rectal Carcinomas.Frontiers in oncology · 2019Article
- Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors.Human genome variation · 2015Article
- Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin.BMC cancer · 2010Article
- Approach to early-onset colorectal cancer: clinicopathological, familial, molecular and immunohistochemical characteristics.World journal of gastroenterology · 2010Article
- Colorectal cancer, one entity or three.Journal of Zhejiang University. Science. B · 2009Review
- Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas.Gastroenterology research and practice · 2009Article
- Sak/Plk4 and mitotic fidelity.Oncogene · 2005Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopment of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability (CIN) pathways. Colorectal cancers in patients under 50 years of age represent about 5% of the total number of tumors and have been associated with an increased frequency of MSI tumors. However, MSI and CIN may play different roles in the development of colon cancer and rectal cancer, and we have specifically investigated their contribution to the development of rectal cancer at young age.
methodsThirty rectal cancers diagnosed before the age of 50 were characterized for DNA-ploidy, MSI, mutations of KRAS and CTNNB1 and immunohistochemical expression of p53, beta-catenin and of the mismatch repair (MMR) proteins MLH1 and MSH2.
resultsDNA aneuploidy was detected in 21/30 tumors, KRAS mutations in 6 tumors, no mutations of CTNNB1 were detected but immunohistochemical staining for beta-catenin showed nuclear staining in 6 tumors, and immunohistochemical expression of p53 was detected in 18 tumors. MSI was detected in 3/30 tumors, all of which showed and immunohistochemical loss of staining for the MMR protein MSH2, which strongly indicates a phenotype associated with hereditary nonpolyposis colorectal cancer (HNPCC).
conclusionsMSI occurs only in a small fraction of the tumors from young patients with rectal cancer, but when present it strongly indicates an underlying HNPCC-causing mutation, and other mechanisms than HNPCC thus cause rectal cancer in the majority of young patients.
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