ArticleWorld journal of gastroenterology2002
Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Three initial diets for management of mild acute pancreatitis: a meta-analysis.World journal of gastroenterology · 2011Pooled it
- Acinar-derived VEGF-A orchestrates blood vascular remodeling and preserves microvessels during acute pancreatitis.Cell communication and signaling : CCS · 2025Article
- Establishment of a Rat Model of Capillary Leakage Syndrome Induced by Cardiopulmonary Resuscitation After Cardiac Arrest.Current medical science · 2023Article
- Experimental isolation and preservation of solid organs before transplantation: effects of pretreatment using four different molecules.The Journal of international medical research · 2020Article
- Fluid resuscitation via the rectum ameliorates hemodynamic disorders through adjusting aquaporin expression in an experimental severe acute pancreatitis model.Experimental and therapeutic medicine · 2019Article
- Non-liquid as initial meal in mild acute pancreatitis: Renewed meta-analysis.JGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Effects of Local Pancreatic Renin-Angiotensin System on the Microcirculation of Rat with Severe Acute Pancreatitis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2015Article
- Complex role for the immune system in initiation and progression of pancreatic cancer.World journal of gastroenterology · 2014Review
- Effects of intensive insulin therapy combined with low molecular weight heparin anticoagulant therapy on severe pancreatitis.Experimental and therapeutic medicine · 2014Article
- Hepatic abnormal perfusion visible by magnetic resonance imaging in acute pancreatitis.World journal of radiology · 2013Article
- N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis.Gut and liver · 2013Article
- The beneficial effects of pentoxifylline on caerulein-induced acute pancreatitis in rats.Digestive diseases and sciences · 2009Article
- Organ failure associated with acute pancreatitis in African-American and Hispanic patients.Journal of the National Medical Association · 2007Article
- Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis.World journal of gastroenterology · 2006Article
- Preventive effect of tetramethylpyrazine on intestinal mucosal injury in rats with acute necrotizing pancreatitis.World journal of gastroenterology · 2006Article
- Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis.World journal of gastroenterology · 2005Article
- Effect of endothelin-1 receptor antagonists on histological and ultrastructural changes in the pancreas and trypsinogen activation in the early course of caerulein-induced acute pancreatitis in rats.World journal of gastroenterology · 2005Article
- Heparin improves organ microcirculatory disturbances in caerulein-induced acute pancreatitis in rats.World journal of gastroenterology · 2004Article
- Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis.World journal of gastroenterology · 2004Article
- Protective effects of rhubarb on experimental severe acute pancreatitis.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the feature of pancreatic microcirculatory impairment, especially the initial changes, in caerulein-induced experimental acute pancreatitis (AP).
methodsThe pancreatic microcirculation of caerulein-induced AP model was studied by intravital fluorescence microscopy with FITC-labeled erythrocytes (FITC-RBC), scanning electron microscopy of vascular corrosion casts, and light microscopy of Chinese ink-injected/cleared tissues.
resultsAnimals in caerulein-treated group showed hyperamylemia (X2), pancreatic oedema, infiltration of inflammatory cells in pancreas. Constrictions of intralobular arteriolar sphincters, presence of vacuoles in all layers of sphincter, and gross irregularity in capillary network of acini were found in the AP specimens. The decrease of pancreatic capillary blood flow (0.34+/-0.10 nl x min(-1) vs 0.91+/-0.06 nl x min(-1) of control, P<0.001), reduction of functional capillary density(277+/-13 cm(-1) vs 349+/-8 cm(-1) of control, P<0.001), and irregular intermittent perfusion were observed in caerulein-induced groups.
conclusionImpairment and constriction of pancreatic intralobular arteriolar sphincter are the initial microcirculatory lesions in the early phase of acute pancreatitis, and play a key role in the pancreatic ischaemia and pancreatic microvascular failure in acute pancreatitis.
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