ArticleWorld journal of gastroenterology2002
Expression of p53 and C-myc genes and its clinical relevance in the hepatocellular carcinomatous and pericarcinomatous tissues.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- The molecular features of lung cancer stem cells in dedifferentiation process-driven epigenetic alterations.The Journal of biological chemistry · 2024Review
- LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling.Theranostics · 2020Article
- Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948.World journal of gastroenterology · 2012Article
- The prevalence of the mutation in codon 249 of the P53 gene in patients with hepatocellular carcinoma (HCC) in Turkey.Journal of gastrointestinal cancer · 2010Article
- ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells.World journal of gastroenterology · 2007Article
- Effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinoma patients undergoing tumor resection.World journal of gastroenterology · 2004Article
- Antisense oligonucleotide targeting at the initiator of hTERT arrests growth of hepatoma cells.World journal of gastroenterology · 2004Article
- Peroxisome proliferator-activated receptor gamma ligands inhibit cell growth and induce apoptosis in human liver cancer BEL-7402 cells.World journal of gastroenterology · 2003Article
- Maxizyme-mediated specific inhibition on mutant-type p53 in vitro.World journal of gastroenterology · 2003Article
- PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells.World journal of gastroenterology · 2003Article
- Effect of arsenic trioxide on rat hepatocellular carcinoma and its renal cytotoxity.World journal of gastroenterology · 2003Article
- Codon 249 mutation in exon 7 of p53 gene in plasma DNA: maybe a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China.World journal of gastroenterology · 2003Article
- Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule (LHN) and hepatocellular carcinoma(HCC).
methodsThe expression of p53 and C-myc genes was detected immunohistochemically in 73 and 60 cases of HCC and pericarcinomatous tissues, respectively.
resultsThe positive expression of p53 in HCC was significantly higher than that in pericarcinomatous tissues (P<0.05). In pericarcinomatous tissues, the p53 expression was observed only in LHN, but not in liver cirrhosis (LC) and normal liver tissues. The positive expression rate of C-myc in HCC or LHN was significantly higher than that in LC or normal liver tissues (P<0.05 and P<0.01), however, no significant difference was found between HCC and LHN (P>0.05). The positive expression rate of p53 and C-myc in HCC was correlated with the histological differentiation, that in the poorly differentiated was significantly higher than that in well differentiated samples (P<0.05).
conclusionThe overexpression of p53 and C-myc genes might play a role in the carcinogenesis of HCC; And LHN seems a preneoplastic lesion related to hepatocarcinogenesis; No evidence supports that LC contribute directly to the hepatocarcinogenesis.
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