ArticlePlant physiology2002
Changes in the antioxidant systems as part of the signaling pathway responsible for the programmed cell death activated by nitric oxide and reactive oxygen species in tobacco Bright-Yellow 2 cells.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 260 citations in OpenAlex.
- Article
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B-induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower.PloS one · 2024Article
- The Hsp90 Inhibitor 17-DMAG Attenuates Hyperglycemia-Enhanced Hemorrhagic Transformation in Experimental Stroke.BioMed research international · 2021Article
- Canavanine Increases the Content of Phenolic Compounds in Tomato (Plants (Basel, Switzerland) · 2020Article
- The arbuscular mycorrhizal mycelium from barley differentially influences various defense parameters in the non-host sugar beet under co-cultivation.Mycorrhiza · 2020Article
- High Light-Induced Nitric Oxide Production Induces Autophagy and Cell Death inFrontiers in plant science · 2020Article
- Vitamin C in Plants: From Functions to Biofortification.Antioxidants (Basel, Switzerland) · 2019Review
- Visualization of Nitric Oxide, Measurement of Nitrosothiols Content, Activity of NOS and NR in Wheat Seedlings.Bio-protocol · 2019Article
- Elevated COProtoplasma · 2019Article
- Lipopolysaccharide-induced priming enhances NO-mediated activation of defense responses in pearl millet challenged with3 Biotech · 2018Article
- HFrontiers in plant science · 2018Article
- Article
- Interaction of Polyamines, Abscisic Acid, Nitric Oxide, and Hydrogen Peroxide under Chilling Stress in Tomato (Frontiers in plant science · 2017Article
- Change of antioxidant enzymes activity of hazel (Corylus avellana L.) cells by AgNPs.Cytotechnology · 2016Article
- Cyclic AMP deficiency negatively affects cell growth and enhances stress-related responses in tobacco Bright Yellow-2 cells.Plant molecular biology · 2016Article
- Involvement of DNA methylation in the control of cell growth during heat stress in tobacco BY-2 cells.Protoplasma · 2015Article
- Over-expression of Trxo1 increases the viability of tobacco BY-2 cells under H2O2 treatment.Annals of botany · 2015Article
- Silicon does not mitigate cell death in cultured tobacco BY-2 cells subjected to salinity without ethylene emission.Plant cell reports · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) has been postulated to be required, together with reactive oxygen species (ROS), for the activation of the hypersensitive reaction, a defense response induced in the noncompatible plant-pathogen interaction. However, its involvement in activating programmed cell death (PCD) in plant cells has been questioned. In this paper, the involvement of the cellular antioxidant metabolism in the signal transduction triggered by these bioactive molecules has been investigated. NO and ROS levels were singularly or simultaneously increased in tobacco (Nicotiana tabacum cv Bright-Yellow 2) cells by the addition to the culture medium of NO and/or ROS generators. The individual increase in NO or ROS had different effects on the studied parameters than the simultaneous increase in the two reactive species. NO generation did not cause an increase in phenylalanine ammonia-lyase (PAL) activity or induction of cellular death. It only induced minor changes in ascorbate (ASC) and glutathione (GSH) metabolisms. An increase in ROS induced oxidative stress in the cells, causing an oxidation of the ASC and GSH redox pairs; however, it had no effect on PAL activity and did not induce cell death when it was generated at low concentrations. In contrast, the simultaneous increase of NO and ROS activated a process of death with the typical cytological and biochemical features of hypersensitive PCD and a remarkable rise in PAL activity. Under the simultaneous generation of NO and ROS, the cellular antioxidant capabilities were also suppressed. The involvement of ASC and GSH as part of the transduction pathway leading to PCD is discussed.
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