ArticlePlant physiology2002
Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 280 papers.
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280 citing papers in PubMed.
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- Glycine max DREB1D transcription factor regulates plant height by reducing gibberellin levels and response.Planta · 2026Article
- Comparative transcriptomics of biopesticide-treated olives subjected to Xylella infection.BMC plant biology · 2026Article
- Integrating high-throughput phenomics and GWAS unravels the HaCBF4-Horticulture research · 2026Article
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- From Shared Mechanisms to Precision Breeding: Engineering Cold and Drought Cross-Tolerance in Crops.International journal of molecular sciences · 2026Review
- Genome-wide analysis of the DREB gene family and functional characterization of HaDREB1D in the drought stress response in sunflower (Helianthus annuus L.).BMC genomics · 2026Article
- deepTFBS: Improving within- and Cross-Species Prediction of Transcription Factor Binding Using Deep Multi-Task and Transfer Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular Networks Governing Plant Responses to Heat and Cold Stress.Plants (Basel, Switzerland) · 2025Review
- Genome-wide analysis of C-repeat binding factor (CBF) family members in Pennisetum glaucum and the function of PgCBF21 under cold stress.BMC plant biology · 2025Article
- Physiological and transcriptomic evaluation of salt tolerance in Egyptian tomato landraces at the seedling stage.BMC plant biology · 2025Article
- Genome-wide identification and expression analysis of CBF/DREB1 gene family in Medicago sativa L. and functional verification of MsCBF9 affecting flowering time.BMC plant biology · 2025Article
- Transcriptome sequencing and functional analysis revealFrontiers in plant science · 2025Article
- Molecular Mechanisms Underlying Freezing Tolerance in Plants: Implications for Cryopreservation.International journal of molecular sciences · 2024Review
- Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.Molecular biology and evolution · 2024Article
- Overexpression of aInternational journal of molecular sciences · 2024Article
- Identification and Characterization of thePlants (Basel, Switzerland) · 2024Article
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2024Article
220 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
In plants, low temperature and dehydration activate a set of genes containing C-repeat/dehydration-responsive elements in their promoter. It has been shown previously that the Arabidopsis CBF/DREB1 transcription activators are critical regulators of gene expression in the signal transduction of cold acclimation. Here, we report the isolation of an apparent homolog of the CBF/DREB1 proteins (CBF4) that plays the equivalent role during drought adaptation. In contrast to the three already identified CBF/DREB1 homologs, which are induced under cold stress, CBF4 gene expression is up-regulated by drought stress, but not by low temperature. Overexpression of CBF4 in transgenic Arabidopsis plants results in the activation of C-repeat/dehydration-responsive element containing downstream genes that are involved in cold acclimation and drought adaptation. As a result, the transgenic plants are more tolerant to freezing and drought stress. Because of the physiological similarity between freezing and drought stress, and the sequence and structural similarity of the CBF/DREB1 and the CBF4 proteins, we propose that the plant's response to cold and drought evolved from a common CBF-like transcription factor, first through gene duplication and then through promoter evolution.
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